Embryonic Stem Cells Are Redirected to Non-Tumorigenic Epithelial Cell Fate by Interaction with the Mammary Microenvironment

Corinne A. Boulanger; Robert D. Bruno; David L. Mack; Monica Gonzales; Nadia P. Castro; David S. Salomon; Gilbert H. Smith

doi:10.1371/journal.pone.0062019

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Research Article

Embryonic Stem Cells Are Redirected to Non-Tumorigenic Epithelial Cell Fate by Interaction with the Mammary Microenvironment

Corinne A. Boulanger ,

Contributed equally to this work with: Corinne A. Boulanger, Robert D. Bruno

Affiliation Mammary Stem Cell Biology Section, Cell and Cancer Biology Branch, National Cancer Institute, Bethesda, Maryland, United States of America
⨯
Robert D. Bruno ,

Contributed equally to this work with: Corinne A. Boulanger, Robert D. Bruno

Affiliation Mammary Stem Cell Biology Section, Cell and Cancer Biology Branch, National Cancer Institute, Bethesda, Maryland, United States of America
⨯
David L. Mack,

Current address: Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, Washington, United States of America

Affiliation Mammary Stem Cell Biology Section, Cell and Cancer Biology Branch, National Cancer Institute, Bethesda, Maryland, United States of America
⨯
Monica Gonzales,

Affiliation Tumor Growth Factor Section, Mammary Biology and Tumorigenesis Laboratory, National Cancer Institute, Bethesda, Maryland, United States of America
⨯
Nadia P. Castro,

Affiliation Tumor Growth Factor Section, Mammary Biology and Tumorigenesis Laboratory, National Cancer Institute, Bethesda, Maryland, United States of America
⨯
David S. Salomon,

Current address: Laboratory of Cancer Prevention, Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America

Affiliation Tumor Growth Factor Section, Mammary Biology and Tumorigenesis Laboratory, National Cancer Institute, Bethesda, Maryland, United States of America
⨯
Gilbert H. Smith

* E-mail: gs4d@nih.gov

Affiliation Mammary Stem Cell Biology Section, Cell and Cancer Biology Branch, National Cancer Institute, Bethesda, Maryland, United States of America
⨯

Embryonic Stem Cells Are Redirected to Non-Tumorigenic Epithelial Cell Fate by Interaction with the Mammary Microenvironment

Corinne A. Boulanger,
Robert D. Bruno,
David L. Mack,
Monica Gonzales,
Nadia P. Castro,
David S. Salomon,
Gilbert H. Smith

Published: April 26, 2013
https://doi.org/10.1371/journal.pone.0062019

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Epithelial cells
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Teratoma
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Cell differentiation
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Breast cancer
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Cell staining
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Mammary glands
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Differentiated tumors
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