Severe Liver Cirrhosis Markedly Reduces AhR-Mediated Induction of Cytochrome P450 in Rats by Decreasing the Transcription of Target Genes

Maura Floreani; Sara De Martin; Daniela Gabbia; Massimo Barbierato; Alberto Nassi; Claudia Mescoli; Rocco Orlando; Sergio Bova; Paolo Angeli; Elisabetta Gola; Antonietta Sticca; Pietro Palatini

doi:10.1371/journal.pone.0061983

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Open Access

Peer-reviewed

Research Article

Severe Liver Cirrhosis Markedly Reduces AhR-Mediated Induction of Cytochrome P450 in Rats by Decreasing the Transcription of Target Genes

Maura Floreani,

Affiliation Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Padova, Italy
⨯
Sara De Martin,

Affiliation Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Padova, Italy
⨯
Daniela Gabbia,

Affiliation Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Padova, Italy
⨯
Massimo Barbierato,

Affiliation Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Padova, Italy
⨯
Alberto Nassi,

Affiliation Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Padova, Italy
⨯
Claudia Mescoli,

Affiliation Surgical Pathology and Cytopathology Unit, Department of Medicine, University of Padova, Padova, Italy
⨯
Rocco Orlando,

Affiliation Laboratory of Experimental Hepatology, Department of Medicine, University of Padova, Padova, Italy
⨯
Sergio Bova,

Affiliation Laboratory of Experimental Hepatology, Department of Medicine, University of Padova, Padova, Italy
⨯
Paolo Angeli,

Affiliation Laboratory of Experimental Hepatology, Department of Medicine, University of Padova, Padova, Italy
⨯
Elisabetta Gola,

Affiliation Laboratory of Experimental Hepatology, Department of Medicine, University of Padova, Padova, Italy
⨯
Antonietta Sticca,

Affiliation Laboratory of Experimental Hepatology, Department of Medicine, University of Padova, Padova, Italy
⨯
Pietro Palatini

* E-mail: pietro.palatini@unipd.it

Affiliation Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Padova, Italy
⨯

Severe Liver Cirrhosis Markedly Reduces AhR-Mediated Induction of Cytochrome P450 in Rats by Decreasing the Transcription of Target Genes

Maura Floreani,
Sara De Martin,
Daniela Gabbia,
Massimo Barbierato,
Alberto Nassi,
Claudia Mescoli,
Rocco Orlando,
Sergio Bova,
Paolo Angeli,
Elisabetta Gola

Published: April 23, 2013
https://doi.org/10.1371/journal.pone.0061983

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Cirrhosis
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Protein expression
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Messenger RNA
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Ascites
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DNA transcription
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Histological examination
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