Crystal Structure of an Anti-Ang2 CrossFab Demonstrates Complete Structural and Functional Integrity of the Variable Domain

• Sebastian Fenn ,

  Contributed equally to this work with: Sebastian Fenn, Christian B. Schiller

  Affiliation Large Molecule Research, Pharma Research and Early Development (pRED), Roche Dignostics GmbH, Penzberg, Germany

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• Christian B. Schiller ,

  Contributed equally to this work with: Sebastian Fenn, Christian B. Schiller

  Affiliation Department of Biochemistry, Gene Center, Ludwig Maximilians University Munich, Munich, Germany

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• Julia J. Griese,

  Current address: Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden

  Affiliation Department of Biochemistry, Gene Center, Ludwig Maximilians University Munich, Munich, Germany

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• Harald Duerr,

  Affiliation Large Molecule Research, Pharma Research and Early Development (pRED), Roche Dignostics GmbH, Penzberg, Germany

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• Sabine Imhof-Jung,

  Affiliation Large Molecule Research, Pharma Research and Early Development (pRED), Roche Dignostics GmbH, Penzberg, Germany

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• Christian Gassner,

  Affiliation Large Molecule Research, Pharma Research and Early Development (pRED), Roche Dignostics GmbH, Penzberg, Germany

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• Joerg Moelleken,

  Affiliation Large Molecule Research, Pharma Research and Early Development (pRED), Roche Dignostics GmbH, Penzberg, Germany

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• Joerg Thomas Regula,

  Affiliation Large Molecule Research, Pharma Research and Early Development (pRED), Roche Dignostics GmbH, Penzberg, Germany

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• Wolfgang Schaefer,

  Affiliation Large Molecule Research, Pharma Research and Early Development (pRED), Roche Dignostics GmbH, Penzberg, Germany

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• Markus Thomas,

  Affiliation Discovery Oncology, Pharma Research and Early Development (pRED), Roche Diagnostics GmbH, Penzberg, Germany

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• Christian Klein,

  Affiliation Discovery Oncology; Pharma Research and Early Development (pRED); Roche Glycart AG, Schlieren, Switzerland

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• Karl-Peter Hopfner ,

  * E-mail: hopfner@lmb.uni-muenchen.de (KH); hubert.kettenberger@roche.com (HK)

  Affiliation Department of Biochemistry, Gene Center, Ludwig Maximilians University Munich, Munich, Germany

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• Hubert Kettenberger

  * E-mail: hopfner@lmb.uni-muenchen.de (KH); hubert.kettenberger@roche.com (HK)

  Affiliation Large Molecule Research, Pharma Research and Early Development (pRED), Roche Dignostics GmbH, Penzberg, Germany

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