Androgens Upregulate Cdc25C Protein by Inhibiting Its Proteasomal and Lysosomal Degradation Pathways

Yu-Wei Chou; Li Zhang; Sakthivel Muniyan; Humera Ahmad; Satyendra Kumar; Syed Mahfuzul Alam; Ming-Fong Lin

doi:10.1371/journal.pone.0061934

Loading metrics

Open Access

Peer-reviewed

Research Article

Androgens Upregulate Cdc25C Protein by Inhibiting Its Proteasomal and Lysosomal Degradation Pathways

Yu-Wei Chou ,

Contributed equally to this work with: Yu-Wei Chou, Li Zhang

Affiliation Department of Biochemistry and Molecular Biology, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
⨯
Li Zhang ,

Contributed equally to this work with: Yu-Wei Chou, Li Zhang

Affiliations Department of Biochemistry and Molecular Biology, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska, United States of America, Beijing Friendship Hospital affiliated to the Capital Medical University, Beijing Digestive Disease Center, Beijing, China
⨯
Sakthivel Muniyan,

Affiliation Department of Biochemistry and Molecular Biology, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
⨯
Humera Ahmad,

Affiliation Department of Biochemistry and Molecular Biology, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
⨯
Satyendra Kumar,

Affiliation Department of Biochemistry and Molecular Biology, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
⨯
Syed Mahfuzul Alam,

Affiliation Department of Biochemistry and Molecular Biology, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
⨯
Ming-Fong Lin

* E-mail: mlin@unmc.edu

Affiliations Department of Biochemistry and Molecular Biology, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska, United States of America, Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska, United States of America, Department of Surgery/Urology, University of Nebraska Medical Center, Omaha, Nebraska, United States of America, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC
⨯

Androgens Upregulate Cdc25C Protein by Inhibiting Its Proteasomal and Lysosomal Degradation Pathways

Yu-Wei Chou,
Li Zhang,
Sakthivel Muniyan,
Humera Ahmad,
Satyendra Kumar,
Syed Mahfuzul Alam,
Ming-Fong Lin

Published: April 18, 2013
https://doi.org/10.1371/journal.pone.0061934

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Cyclins
Is the Subject Area "Cyclins" applicable to this article?

Thanks for your feedback.
Androgens
Is the Subject Area "Androgens" applicable to this article?

Thanks for your feedback.
Prostate cancer
Is the Subject Area "Prostate cancer" applicable to this article?

Thanks for your feedback.
Cell proliferation
Is the Subject Area "Cell proliferation" applicable to this article?

Thanks for your feedback.
Cell cycle and cell division
Is the Subject Area "Cell cycle and cell division" applicable to this article?

Thanks for your feedback.
Transfection
Is the Subject Area "Transfection" applicable to this article?

Thanks for your feedback.
Cell growth
Is the Subject Area "Cell growth" applicable to this article?

Thanks for your feedback.
Phosphorylation
Is the Subject Area "Phosphorylation" applicable to this article?

Thanks for your feedback.