Ultra-Rare Mutation in Long-Range Enhancer Predisposes to Thyroid Carcinoma with High Penetrance

• Huiling He ,

  * E-mail: huiling.he@osumc.edu (HH); albert.delachapelle@osumc.edu (AdlC)

  Affiliation Human Cancer Genetics Program and Department of Molecular Virology, Immunology and Medical Genetics, Ohio State University Wexner Medical Center and Comprehensive Cancer Center, the Ohio State University, Columbus, Ohio, United States of America

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• Wei Li,

  Affiliation Human Cancer Genetics Program and Department of Molecular Virology, Immunology and Medical Genetics, Ohio State University Wexner Medical Center and Comprehensive Cancer Center, the Ohio State University, Columbus, Ohio, United States of America

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• Dayong Wu,

  Affiliation Department of Molecular and Cellular Biochemistry, Ohio State University Wexner Medical Center and Comprehensive Cancer Center, the Ohio State University, Columbus, Ohio, United States of America

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• Rebecca Nagy,

  Affiliations Human Cancer Genetics Program and Department of Molecular Virology, Immunology and Medical Genetics, Ohio State University Wexner Medical Center and Comprehensive Cancer Center, the Ohio State University, Columbus, Ohio, United States of America, Department of Internal Medicine, Ohio State University Wexner Medical Center and Comprehensive Cancer Center, the Ohio State University, Columbus, Ohio, United States of America

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• Sandya Liyanarachchi,

  Affiliation Human Cancer Genetics Program and Department of Molecular Virology, Immunology and Medical Genetics, Ohio State University Wexner Medical Center and Comprehensive Cancer Center, the Ohio State University, Columbus, Ohio, United States of America

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• Keiko Akagi,

  Affiliation Human Cancer Genetics Program and Department of Molecular Virology, Immunology and Medical Genetics, Ohio State University Wexner Medical Center and Comprehensive Cancer Center, the Ohio State University, Columbus, Ohio, United States of America

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• Jaroslaw Jendrzejewski,

  Affiliation Human Cancer Genetics Program and Department of Molecular Virology, Immunology and Medical Genetics, Ohio State University Wexner Medical Center and Comprehensive Cancer Center, the Ohio State University, Columbus, Ohio, United States of America

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• Hong Jiao,

  Affiliation Department of Biosciences and Nutrition, Clinical Research Centre, and Science for Life Laboratory, Karolinska Institutet, Stockholm, Sweden

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• Kevin Hoag,

  Affiliation Human Cancer Genetics Program and Department of Molecular Virology, Immunology and Medical Genetics, Ohio State University Wexner Medical Center and Comprehensive Cancer Center, the Ohio State University, Columbus, Ohio, United States of America

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• Bernard Wen,

  Affiliation Human Cancer Genetics Program and Department of Molecular Virology, Immunology and Medical Genetics, Ohio State University Wexner Medical Center and Comprehensive Cancer Center, the Ohio State University, Columbus, Ohio, United States of America

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• Mukund Srinivas,

  Affiliation Human Cancer Genetics Program and Department of Molecular Virology, Immunology and Medical Genetics, Ohio State University Wexner Medical Center and Comprehensive Cancer Center, the Ohio State University, Columbus, Ohio, United States of America

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• Gavisha Waidyaratne,

  Affiliation Human Cancer Genetics Program and Department of Molecular Virology, Immunology and Medical Genetics, Ohio State University Wexner Medical Center and Comprehensive Cancer Center, the Ohio State University, Columbus, Ohio, United States of America

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• Rui Wang,

  Affiliation Department of Biomedical Informatics, Ohio State University Wexner Medical Center and Comprehensive Cancer Center, the Ohio State University, Columbus, Ohio, United States of America

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• Anna Wojcicka,

  Affiliations Department of Biochemistry and Molecular Biology, Medical Centre of Postgraduate Education, Warsaw, Poland, Genomic Medicine, Department of General, Transplant, and Liver Surgery, Medical University of Warsaw, Warsaw, Poland

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• Ilene R. Lattimer,

  Affiliations Human Cancer Genetics Program and Department of Molecular Virology, Immunology and Medical Genetics, Ohio State University Wexner Medical Center and Comprehensive Cancer Center, the Ohio State University, Columbus, Ohio, United States of America, Department of Internal Medicine, Ohio State University Wexner Medical Center and Comprehensive Cancer Center, the Ohio State University, Columbus, Ohio, United States of America

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• Elzbieta Stachlewska,

  Affiliation Department of Endocrine Surgery, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland

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• Malgorzata Czetwertynska,

  Affiliation Department of Nuclear Medicine and Endocrine Oncology, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland

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• Joanna Dlugosinska,

  Affiliation Department of Nuclear Medicine and Endocrine Oncology, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland

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• Wojciech Gierlikowski,

  Affiliation Genomic Medicine, Department of General, Transplant, and Liver Surgery, Medical University of Warsaw, Warsaw, Poland

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• Rafal Ploski,

  Affiliation Department of Medical Genetics, Medical University of Warsaw, Warsaw, Poland

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• Marek Krawczyk,

  Affiliation Genomic Medicine, Department of General, Transplant, and Liver Surgery, Medical University of Warsaw, Warsaw, Poland

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• Krystian Jazdzewski,

  Affiliations Human Cancer Genetics Program and Department of Molecular Virology, Immunology and Medical Genetics, Ohio State University Wexner Medical Center and Comprehensive Cancer Center, the Ohio State University, Columbus, Ohio, United States of America, Genomic Medicine, Department of General, Transplant, and Liver Surgery, Medical University of Warsaw, Warsaw, Poland

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• Juha Kere,

  Affiliations Department of Biosciences and Nutrition, Clinical Research Centre, and Science for Life Laboratory, Karolinska Institutet, Stockholm, Sweden, Folkhälsan Institute of Genetics, Helsinki, and Research Program's Unit, University of Helsinki, Helsinki, Finland

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• David E. Symer,

  Affiliations Human Cancer Genetics Program and Department of Molecular Virology, Immunology and Medical Genetics, Ohio State University Wexner Medical Center and Comprehensive Cancer Center, the Ohio State University, Columbus, Ohio, United States of America, Department of Internal Medicine, Ohio State University Wexner Medical Center and Comprehensive Cancer Center, the Ohio State University, Columbus, Ohio, United States of America, Department of Biomedical Informatics, Ohio State University Wexner Medical Center and Comprehensive Cancer Center, the Ohio State University, Columbus, Ohio, United States of America

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• Victor Jin,

  Affiliation Department of Biomedical Informatics, Ohio State University Wexner Medical Center and Comprehensive Cancer Center, the Ohio State University, Columbus, Ohio, United States of America

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• Qianben Wang,

  Affiliation Department of Molecular and Cellular Biochemistry, Ohio State University Wexner Medical Center and Comprehensive Cancer Center, the Ohio State University, Columbus, Ohio, United States of America

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•  [ ... ],
• Albert de la Chapelle

  * E-mail: huiling.he@osumc.edu (HH); albert.delachapelle@osumc.edu (AdlC)

  Affiliation Human Cancer Genetics Program and Department of Molecular Virology, Immunology and Medical Genetics, Ohio State University Wexner Medical Center and Comprehensive Cancer Center, the Ohio State University, Columbus, Ohio, United States of America

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