Common Genetic Variation in the Human FNDC5 Locus, Encoding the Novel Muscle-Derived ‘Browning’ Factor Irisin, Determines Insulin Sensitivity

• Harald Staiger,

  Affiliations Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology and Clinical Chemistry, Eberhard Karls University Tübingen, Tübingen, Germany, Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Centre Munich at the University of Tübingen, Tübingen, Germany, German Centre for Diabetes Research (DZD), Neuherberg, Germany

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• Anja Böhm,

  Affiliations Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology and Clinical Chemistry, Eberhard Karls University Tübingen, Tübingen, Germany, German Centre for Diabetes Research (DZD), Neuherberg, Germany, Institute of Experimental Genetics, Helmholtz Centre Munich, German Research Centre for Environmental Health, Neuherberg, Germany

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• Mika Scheler,

  Affiliations German Centre for Diabetes Research (DZD), Neuherberg, Germany, Institute of Experimental Genetics, Helmholtz Centre Munich, German Research Centre for Environmental Health, Neuherberg, Germany

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• Lucia Berti,

  Affiliations German Centre for Diabetes Research (DZD), Neuherberg, Germany, Institute of Experimental Genetics, Helmholtz Centre Munich, German Research Centre for Environmental Health, Neuherberg, Germany

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• Jürgen Machann,

  Affiliations Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Centre Munich at the University of Tübingen, Tübingen, Germany, German Centre for Diabetes Research (DZD), Neuherberg, Germany, Department of Diagnostic and Interventional Radiology, Section on Experimental Radiology, Eberhard Karls University Tübingen, Tübingen, Germany

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• Fritz Schick,

  Affiliations Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Centre Munich at the University of Tübingen, Tübingen, Germany, German Centre for Diabetes Research (DZD), Neuherberg, Germany, Department of Diagnostic and Interventional Radiology, Section on Experimental Radiology, Eberhard Karls University Tübingen, Tübingen, Germany

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• Fausto Machicao,

  Affiliations Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Centre Munich at the University of Tübingen, Tübingen, Germany, German Centre for Diabetes Research (DZD), Neuherberg, Germany

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• Andreas Fritsche,

  Affiliations Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology and Clinical Chemistry, Eberhard Karls University Tübingen, Tübingen, Germany, Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Centre Munich at the University of Tübingen, Tübingen, Germany, German Centre for Diabetes Research (DZD), Neuherberg, Germany, Department of Internal Medicine, Division of Nutritional and Preventive Medicine, Eberhard Karls University Tübingen, Tübingen, Germany

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• Norbert Stefan,

  Affiliations Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology and Clinical Chemistry, Eberhard Karls University Tübingen, Tübingen, Germany, Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Centre Munich at the University of Tübingen, Tübingen, Germany, German Centre for Diabetes Research (DZD), Neuherberg, Germany

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• Cora Weigert,

  Affiliations Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology and Clinical Chemistry, Eberhard Karls University Tübingen, Tübingen, Germany, Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Centre Munich at the University of Tübingen, Tübingen, Germany, German Centre for Diabetes Research (DZD), Neuherberg, Germany

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• Anna Krook,

  Affiliation Department of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden

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• Hans-Ulrich Häring ,

  * E-mail: hans-ulrich.haering@med.uni-tuebingen.de (H-UH); hrabe@helmholtz-muenchen.de (MHdA)

  Affiliations Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology and Clinical Chemistry, Eberhard Karls University Tübingen, Tübingen, Germany, Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Centre Munich at the University of Tübingen, Tübingen, Germany, German Centre for Diabetes Research (DZD), Neuherberg, Germany, Institute of Experimental Genetics, Helmholtz Centre Munich, German Research Centre for Environmental Health, Neuherberg, Germany

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• Martin Hrabě de Angelis

  * E-mail: hans-ulrich.haering@med.uni-tuebingen.de (H-UH); hrabe@helmholtz-muenchen.de (MHdA)

  Affiliations German Centre for Diabetes Research (DZD), Neuherberg, Germany, Institute of Experimental Genetics, Helmholtz Centre Munich, German Research Centre for Environmental Health, Neuherberg, Germany, Chair for Experimental Genetics, Technical University Munich, Freising, Germany

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