DNA-Bound Platinum Is the Major Determinant of Cisplatin Sensitivity in Head and Neck Squamous Carcinoma Cells

Open Access

Peer-reviewed

Research Article

Sanne R. Martens-de Kemp,

Affiliation Department of Otolaryngology/Head-Neck Surgery, VU University Medical Center, Amsterdam, The Netherlands
⨯
Simone U. Dalm,

Affiliation Department of Otolaryngology/Head-Neck Surgery, VU University Medical Center, Amsterdam, The Netherlands
⨯
Fiona M. J. Wijnolts,

Affiliation Department of Otolaryngology/Head-Neck Surgery, VU University Medical Center, Amsterdam, The Netherlands
⨯
Arjen Brink,

Affiliation Department of Otolaryngology/Head-Neck Surgery, VU University Medical Center, Amsterdam, The Netherlands
⨯
Richard J. Honeywell,

Affiliation Department of Medical Oncology, VU University Medical Center, Amsterdam, The Netherlands
⨯
Godefridus J. Peters,

Affiliation Department of Medical Oncology, VU University Medical Center, Amsterdam, The Netherlands
⨯
Boudewijn J. M. Braakhuis,

Affiliation Department of Otolaryngology/Head-Neck Surgery, VU University Medical Center, Amsterdam, The Netherlands
⨯
Ruud H. Brakenhoff

* E-mail: rh.brakenhoff@vumc.nl

Affiliation Department of Otolaryngology/Head-Neck Surgery, VU University Medical Center, Amsterdam, The Netherlands
⨯

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Cancer treatment
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DNA repair
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Frameshift mutation
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Nonsense mutation
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Gene expression
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Genetic causes of cancer
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Cancers and neoplasms
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Head and neck squamous cell carcinoma
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