FGF21 Can Be Mimicked In Vitro and In Vivo by a Novel Anti-FGFR1c/β-Klotho Bispecific Protein

Richard Smith; Amy Duguay; Alice Bakker; Peng Li; Jennifer Weiszmann; Melissa R. Thomas; Benjamin M. Alba; Xinle Wu; Jamila Gupte; Li Yang; Jennitte Stevens; Agnes Hamburger; Stephen Smith; Jiyun Chen; Renee Komorowski; Kevin W. Moore; Murielle M. Véniant; Yang Li

doi:10.1371/journal.pone.0061432

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Peer-reviewed

Research Article

FGF21 Can Be Mimicked In Vitro and In Vivo by a Novel Anti-FGFR1c/β-Klotho Bispecific Protein

Richard Smith,

Affiliation Therapeutic Discovery, Amgen Inc., South San Francisco, California, United States of America
⨯
Amy Duguay,

Affiliation Therapeutic Discovery, Amgen Inc., South San Francisco, California, United States of America
⨯
Alice Bakker,

Affiliation Therapeutic Discovery, Amgen Inc., South San Francisco, California, United States of America
⨯
Peng Li,

Affiliation Therapeutic Discovery, Amgen Inc., South San Francisco, California, United States of America
⨯
Jennifer Weiszmann,

Affiliation Metabolic Disorders, Amgen Inc., South San Francisco, California, United States of America
⨯
Melissa R. Thomas,

Affiliation Therapeutic Discovery, Amgen Inc., South San Francisco, California, United States of America
⨯
Benjamin M. Alba,

Affiliation Therapeutic Discovery, Amgen Inc., South San Francisco, California, United States of America
⨯
Xinle Wu,

Affiliation Metabolic Disorders, Amgen Inc., South San Francisco, California, United States of America
⨯
Jamila Gupte,

Affiliation Metabolic Disorders, Amgen Inc., South San Francisco, California, United States of America
⨯
Li Yang,

Affiliation Metabolic Disorders, Amgen Inc., South San Francisco, California, United States of America
⨯
Jennitte Stevens,

Affiliation Therapeutic Discovery, Amgen Inc., Thousand Oaks, California, United States of America
⨯
Agnes Hamburger,

Affiliation Therapeutic Discovery, Amgen Inc., Thousand Oaks, California, United States of America
⨯
Stephen Smith,

Affiliation Therapeutic Discovery, Amgen Inc., Thousand Oaks, California, United States of America
⨯
Jiyun Chen,

Affiliation Pharmacokinetics and Drug Metabolism, Amgen Inc., South San Francisco, California, United States of America
⨯
Renee Komorowski,

Affiliation Metabolic Disorders, Amgen Inc., Thousand Oaks, California, United States of America
⨯
Kevin W. Moore,

Affiliation Therapeutic Discovery, Amgen Inc., South San Francisco, California, United States of America
⨯
Murielle M. Véniant,

Affiliation Metabolic Disorders, Amgen Inc., Thousand Oaks, California, United States of America
⨯
[ ... ],
Yang Li

* E-mail: yangl@amgen.com

Affiliation Metabolic Disorders, Amgen Inc., South San Francisco, California, United States of America
⨯
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FGF21 Can Be Mimicked In Vitro and In Vivo by a Novel Anti-FGFR1c/β-Klotho Bispecific Protein

Richard Smith,
Amy Duguay,
Alice Bakker,
Peng Li,
Jennifer Weiszmann,
Melissa R. Thomas,
Benjamin M. Alba,
Xinle Wu,
Jamila Gupte,
Li Yang

Published: April 22, 2013
https://doi.org/10.1371/journal.pone.0061432

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