Cocaine Inhibits Dopamine D2 Receptor Signaling via Sigma-1-D2 Receptor Heteromers

Gemma Navarro; Estefania Moreno; Jordi Bonaventura; Marc Brugarolas; Daniel Farré; David Aguinaga; Josefa Mallol; Antoni Cortés; Vicent Casadó; Carmen Lluís; Sergi Ferre; Rafael Franco; Enric Canela; Peter J. McCormick

doi:10.1371/journal.pone.0061245

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Research Article

Cocaine Inhibits Dopamine D₂ Receptor Signaling via Sigma-1-D₂ Receptor Heteromers

Gemma Navarro,

Affiliation Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED) and Institute of Biomedicine of the University of Barcelona (IBUB) and Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, Barcelona, Spain
⨯
Estefania Moreno,

Affiliation Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED) and Institute of Biomedicine of the University of Barcelona (IBUB) and Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, Barcelona, Spain
⨯
Jordi Bonaventura,

Affiliation Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED) and Institute of Biomedicine of the University of Barcelona (IBUB) and Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, Barcelona, Spain
⨯
Marc Brugarolas,

Affiliation Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED) and Institute of Biomedicine of the University of Barcelona (IBUB) and Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, Barcelona, Spain
⨯
Daniel Farré,

Affiliation Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED) and Institute of Biomedicine of the University of Barcelona (IBUB) and Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, Barcelona, Spain
⨯
David Aguinaga,

Affiliation Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED) and Institute of Biomedicine of the University of Barcelona (IBUB) and Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, Barcelona, Spain
⨯
Josefa Mallol,

Affiliation Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED) and Institute of Biomedicine of the University of Barcelona (IBUB) and Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, Barcelona, Spain
⨯
Antoni Cortés,

Affiliation Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED) and Institute of Biomedicine of the University of Barcelona (IBUB) and Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, Barcelona, Spain
⨯
Vicent Casadó,

Affiliation Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED) and Institute of Biomedicine of the University of Barcelona (IBUB) and Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, Barcelona, Spain
⨯
Carmen Lluís,

Affiliation Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED) and Institute of Biomedicine of the University of Barcelona (IBUB) and Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, Barcelona, Spain
⨯
Sergi Ferre,

Affiliation National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland, United States of America
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Rafael Franco ,

Contributed equally to this work with: Rafael Franco, Enric Canela, Peter J. McCormick

Affiliation Centro de Investigación Médica Aplicada, Universidad de Navarra, Pamplona, Spain
⨯
Enric Canela ,

Contributed equally to this work with: Rafael Franco, Enric Canela, Peter J. McCormick

Affiliation Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED) and Institute of Biomedicine of the University of Barcelona (IBUB) and Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, Barcelona, Spain
⨯
Peter J. McCormick

Contributed equally to this work with: Rafael Franco, Enric Canela, Peter J. McCormick

* E-mail: pmccormick@ub.edu

Affiliation Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED) and Institute of Biomedicine of the University of Barcelona (IBUB) and Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, Barcelona, Spain
⨯

Cocaine Inhibits Dopamine D₂ Receptor Signaling via Sigma-1-D₂ Receptor Heteromers

Gemma Navarro,
Estefania Moreno,
Jordi Bonaventura,
Marc Brugarolas,
Daniel Farré,
David Aguinaga,
Josefa Mallol,
Antoni Cortés,
Vicent Casadó,
Carmen Lluís

Published: April 18, 2013
https://doi.org/10.1371/journal.pone.0061245

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