Gene Expression Patterns of Hemizygous and Heterozygous KIT Mutations Suggest Distinct Oncogenic Pathways: A Study in NIH3T3 Cell Lines and GIST Samples

Jean-Baptiste Bachet; Séverine Tabone-Eglinger; Sophie Dessaux; Anthony Besse; Sabrina Brahimi-Adouane; Jean-François Emile; Jean-Yves Blay; Laurent Alberti

doi:10.1371/journal.pone.0061103

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Research Article

Gene Expression Patterns of Hemizygous and Heterozygous KIT Mutations Suggest Distinct Oncogenic Pathways: A Study in NIH3T3 Cell Lines and GIST Samples

Jean-Baptiste Bachet ,

Contributed equally to this work with: Jean-Baptiste Bachet, Séverine Tabone-Eglinger

Affiliations EA4340 ‘Epidémiologie et Oncogénèse des tumeurs digestives’, Faculté de médecine PIFO, UVSQ, Guyancourt, France, Hepato-Gastroenterology Department, Groupe Hospitalier Pitié Salpêtrière, APHP, Paris, France, Faculté de médecine Pierre et Marie Curie, UFR Paris VI, Paris, France
⨯
Séverine Tabone-Eglinger ,

Contributed equally to this work with: Jean-Baptiste Bachet, Séverine Tabone-Eglinger

Affiliations Université de Lyon, Lyon, France, Université Lyon 1, ISPB, Lyon, France, INSERM U1052, Centre de Recherche en Cancérologie de Lyon, Lyon, France, CNRS UMR5286, Centre de Recherche en Cancérologie de Lyon, Lyon, France
⨯
Sophie Dessaux,

Affiliations Université de Lyon, Lyon, France, Université Lyon 1, ISPB, Lyon, France, INSERM U1052, Centre de Recherche en Cancérologie de Lyon, Lyon, France, CNRS UMR5286, Centre de Recherche en Cancérologie de Lyon, Lyon, France
⨯
Anthony Besse,

Affiliations Université de Lyon, Lyon, France, Université Lyon 1, ISPB, Lyon, France, INSERM U1052, Centre de Recherche en Cancérologie de Lyon, Lyon, France, CNRS UMR5286, Centre de Recherche en Cancérologie de Lyon, Lyon, France
⨯
Sabrina Brahimi-Adouane,

Affiliations EA4340 ‘Epidémiologie et Oncogénèse des tumeurs digestives’, Faculté de médecine PIFO, UVSQ, Guyancourt, France, Pathology Department, Hôpital Ambroise Paré, APHP, Boulogne, France
⨯
Jean-François Emile,

Affiliations EA4340 ‘Epidémiologie et Oncogénèse des tumeurs digestives’, Faculté de médecine PIFO, UVSQ, Guyancourt, France, Pathology Department, Hôpital Ambroise Paré, APHP, Boulogne, France
⨯
Jean-Yves Blay,

Affiliations Université de Lyon, Lyon, France, Oncology Department, Centre Léon Bérard, Lyon, France
⨯
Laurent Alberti

* E-mail: laurent.alberti@lyon.unicancer.fr

Affiliations Université de Lyon, Lyon, France, Biopathology Department Centre Léon Bérard, Lyon, France
⨯

Gene Expression Patterns of Hemizygous and Heterozygous KIT Mutations Suggest Distinct Oncogenic Pathways: A Study in NIH3T3 Cell Lines and GIST Samples

Jean-Baptiste Bachet,
Séverine Tabone-Eglinger,
Sophie Dessaux,
Anthony Besse,
Sabrina Brahimi-Adouane,
Jean-François Emile,
Jean-Yves Blay,
Laurent Alberti

Published: April 12, 2013
https://doi.org/10.1371/journal.pone.0061103

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Heterozygosity
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MicroRNAs
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Mutation
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Cancers and neoplasms
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Gene expression
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