Regulatory T Lymphocytes Are Associated with Less Aggressive Histologic Features in Microsatellite-Unstable Colorectal Cancers

David Tougeron; Pauline Maby; Nicolas Elie; Émilie Fauquembergue; Florence Le Pessot; Marie Cornic; Jean-Christophe Sabourin; Pierre Michel; Thierry Frébourg; Jean-Baptiste Latouche

doi:10.1371/journal.pone.0061001

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Open Access

Peer-reviewed

Research Article

Regulatory T Lymphocytes Are Associated with Less Aggressive Histologic Features in Microsatellite-Unstable Colorectal Cancers

David Tougeron ,

Contributed equally to this work with: David Tougeron, Pauline Maby

* E-mail: davidtougeron@hotmail.fr

Affiliations Inserm, U1079, Faculty of Medicine, Institute for Medical Research, Rouen University Hospital, Rouen, France, Department of Gastroenterology, Rouen University Hospital, Rouen, France, Department of Gastroenterology, Poitiers University Hospital, Poitiers, France, Laboratoire Inflammation Tissus Epithéliaux et Cytokines, EA 4331, Poitiers University, Poitiers, France
⨯
Pauline Maby ,

Contributed equally to this work with: David Tougeron, Pauline Maby

Affiliation Inserm, U1079, Faculty of Medicine, Institute for Medical Research, Rouen University Hospital, Rouen, France
⨯
Nicolas Elie,

Affiliation Plateau d’Histo-Imagerie Quantitative, CMABIO, Caen University, Caen, France
⨯
Émilie Fauquembergue,

Affiliation Inserm, U1079, Faculty of Medicine, Institute for Medical Research, Rouen University Hospital, Rouen, France
⨯
Florence Le Pessot,

Affiliation Department of Pathology, Rouen University Hospital, Rouen, France
⨯
Marie Cornic,

Affiliation Department of Pathology, Centre Henri Becquerel, Rouen, France
⨯
Jean-Christophe Sabourin,

Affiliations Inserm, U1079, Faculty of Medicine, Institute for Medical Research, Rouen University Hospital, Rouen, France, Department of Pathology, Rouen University Hospital, Rouen, France
⨯
Pierre Michel,

Affiliations Inserm, U1079, Faculty of Medicine, Institute for Medical Research, Rouen University Hospital, Rouen, France, Department of Gastroenterology, Rouen University Hospital, Rouen, France
⨯
Thierry Frébourg,

Affiliation Inserm, U1079, Faculty of Medicine, Institute for Medical Research, Rouen University Hospital, Rouen, France
⨯
Jean-Baptiste Latouche

Affiliation Inserm, U1079, Faculty of Medicine, Institute for Medical Research, Rouen University Hospital, Rouen, France
⨯

Regulatory T Lymphocytes Are Associated with Less Aggressive Histologic Features in Microsatellite-Unstable Colorectal Cancers

David Tougeron,
Pauline Maby,
Nicolas Elie,
Émilie Fauquembergue,
Florence Le Pessot,
Marie Cornic,
Jean-Christophe Sabourin,
Pierre Michel,
Thierry Frébourg,
Jean-Baptiste Latouche

Published: April 15, 2013
https://doi.org/10.1371/journal.pone.0061001

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Colorectal cancer
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Cytotoxic T cells
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T cells
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