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Open Access
Peer-reviewed
Research Article
Tetrahydropyrazolo[1,5-a]Pyrimidine-3-Carboxamide and N-Benzyl-6′,7′-Dihydrospiro[Piperidine-4,4′-Thieno[3,2-c]Pyran] Analogues with Bactericidal Efficacy against Mycobacterium tuberculosis Targeting MmpL3
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Modesto J. Remuiñán ,
* E-mail: Modesto.b.remuinan@gsk.com
Affiliation Diseases of the Developing World, GlaxoSmithKline, Tres Cantos, Madrid, Spain
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Esther Pérez-Herrán,
Affiliation Diseases of the Developing World, GlaxoSmithKline, Tres Cantos, Madrid, Spain
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Joaquín Rullás,
Affiliation Diseases of the Developing World, GlaxoSmithKline, Tres Cantos, Madrid, Spain
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Carlos Alemparte,
Affiliation Diseases of the Developing World, GlaxoSmithKline, Tres Cantos, Madrid, Spain
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María Martínez-Hoyos,
Affiliation Diseases of the Developing World, GlaxoSmithKline, Tres Cantos, Madrid, Spain
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David J. Dow,
Affiliation Molecular and Cellular Technologies, GlaxoSmithKline, Stevenage, United Kingdom
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Johnson Afari,
Affiliation Molecular and Cellular Technologies, GlaxoSmithKline, Stevenage, United Kingdom
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Nalini Mehta,
Affiliation Molecular and Cellular Technologies, GlaxoSmithKline, Stevenage, United Kingdom
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Jorge Esquivias,
Affiliation Diseases of the Developing World, GlaxoSmithKline, Tres Cantos, Madrid, Spain
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Elena Jiménez,
Affiliation Diseases of the Developing World, GlaxoSmithKline, Tres Cantos, Madrid, Spain
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Fátima Ortega-Muro,
Affiliation Diseases of the Developing World, GlaxoSmithKline, Tres Cantos, Madrid, Spain
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María Teresa Fraile-Gabaldón,
Affiliation Diseases of the Developing World, GlaxoSmithKline, Tres Cantos, Madrid, Spain
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Vickey L. Spivey,
Affiliation Molecular and Cellular Technologies, GlaxoSmithKline, Stevenage, United Kingdom
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Nicholas J. Loman,
Affiliation School of Biosciences, University of Birmingham, Edgbaston, United Kingdom
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Mark J. Pallen,
Affiliation School of Biosciences, University of Birmingham, Edgbaston, United Kingdom
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Chrystala Constantinidou,
Affiliation School of Biosciences, University of Birmingham, Edgbaston, United Kingdom
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Douglas J. Minick,
Affiliation Department of Analytical Chemistry, GlaxoSmithKline, Research Triangle Park, North Carolina, United States of America
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Mónica Cacho,
Affiliation Diseases of the Developing World, GlaxoSmithKline, Tres Cantos, Madrid, Spain
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María José Rebollo-López,
Affiliation Diseases of the Developing World, GlaxoSmithKline, Tres Cantos, Madrid, Spain
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Carolina González,
Affiliation Diseases of the Developing World, GlaxoSmithKline, Tres Cantos, Madrid, Spain
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Verónica Sousa,
Affiliation Diseases of the Developing World, GlaxoSmithKline, Tres Cantos, Madrid, Spain
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Iñigo Angulo-Barturen,
Affiliation Diseases of the Developing World, GlaxoSmithKline, Tres Cantos, Madrid, Spain
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Alfonso Mendoza-Losana,
Affiliation Diseases of the Developing World, GlaxoSmithKline, Tres Cantos, Madrid, Spain
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David Barros,
Affiliation Diseases of the Developing World, GlaxoSmithKline, Tres Cantos, Madrid, Spain
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Gurdyal S. Besra,
Affiliation School of Biosciences, University of Birmingham, Edgbaston, United Kingdom
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Lluís Ballell,
Affiliation Diseases of the Developing World, GlaxoSmithKline, Tres Cantos, Madrid, Spain
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Nicholas Cammack
Affiliation Diseases of the Developing World, GlaxoSmithKline, Tres Cantos, Madrid, Spain
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Tetrahydropyrazolo[1,5-a]Pyrimidine-3-Carboxamide and N-Benzyl-6′,7′-Dihydrospiro[Piperidine-4,4′-Thieno[3,2-c]Pyran] Analogues with Bactericidal Efficacy against Mycobacterium tuberculosis Targeting MmpL3
- Modesto J. Remuiñán,
- Esther Pérez-Herrán,
- Joaquín Rullás,
- Carlos Alemparte,
- María Martínez-Hoyos,
- David J. Dow,
- Johnson Afari,
- Nalini Mehta,
- Jorge Esquivias,
- Elena Jiménez
- Published: April 17, 2013
- https://doi.org/10.1371/journal.pone.0060933