EGFP-EGF1-Conjugated PLGA Nanoparticles for Targeted Delivery of siRNA into Injured Brain Microvascular Endothelial Cells for Efficient RNA Interference

Chen Chen; Heng Mei; Wei Shi; Jun Deng; Bo Zhang; Tao Guo; Huafang Wang; Yu Hu

doi:10.1371/journal.pone.0060860

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Open Access

Peer-reviewed

Research Article

EGFP-EGF1-Conjugated PLGA Nanoparticles for Targeted Delivery of siRNA into Injured Brain Microvascular Endothelial Cells for Efficient RNA Interference

Chen Chen,

Affiliations Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China, Targeted Biotherapy Key Laboratory of Ministry of Education, Wuhan, Hubei, PR China
⨯
Heng Mei,

Affiliations Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China, Targeted Biotherapy Key Laboratory of Ministry of Education, Wuhan, Hubei, PR China
⨯
Wei Shi,

Affiliations Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China, Targeted Biotherapy Key Laboratory of Ministry of Education, Wuhan, Hubei, PR China
⨯
Jun Deng,

Affiliations Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China, Targeted Biotherapy Key Laboratory of Ministry of Education, Wuhan, Hubei, PR China
⨯
Bo Zhang,

Affiliations Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China, Targeted Biotherapy Key Laboratory of Ministry of Education, Wuhan, Hubei, PR China
⨯
Tao Guo,

Affiliations Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China, Targeted Biotherapy Key Laboratory of Ministry of Education, Wuhan, Hubei, PR China
⨯
Huafang Wang,

Affiliations Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China, Targeted Biotherapy Key Laboratory of Ministry of Education, Wuhan, Hubei, PR China
⨯
Yu Hu

* E-mail: dr_huyu@126.com

Affiliations Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China, Targeted Biotherapy Key Laboratory of Ministry of Education, Wuhan, Hubei, PR China
⨯

EGFP-EGF1-Conjugated PLGA Nanoparticles for Targeted Delivery of siRNA into Injured Brain Microvascular Endothelial Cells for Efficient RNA Interference

Chen Chen,
Heng Mei,
Wei Shi,
Jun Deng,
Bo Zhang,
Tao Guo,
Huafang Wang,
Yu Hu

Published: April 10, 2013
https://doi.org/10.1371/journal.pone.0060860

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