Identification of Anziaic Acid, a Lichen Depside from Hypotrachyna sp., as a New Topoisomerase Poison Inhibitor

• Bokun Cheng,

  Affiliation Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, New York, United States of America

  ⨯
• Shugeng Cao,

  Affiliation Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, United States of America

  ⨯
• Victor Vasquez,

  Affiliation Unidad Estrategica de Bioprospeccion, Instituto Nacional de Biodiversidad (INBio) and Escuela de Química, Universidad de Costa Rica, San José, Costa Rica

  ⨯
• Thirunavukkarasu Annamalai,

  Affiliations Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, New York, United States of America, Department of Chemistry and Biochemistry, Florida International University, Miami, Florida, United States of America

  ⨯
• Giselle Tamayo-Castillo,

  Affiliation Unidad Estrategica de Bioprospeccion, Instituto Nacional de Biodiversidad (INBio) and Escuela de Química, Universidad de Costa Rica, San José, Costa Rica

  ⨯
• Jon Clardy,

  Affiliation Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, United States of America

  ⨯
• Yuk-Ching Tse-Dinh

  * E-mail: ytsedinh@fiu.edu

  Affiliations Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, New York, United States of America, Department of Chemistry and Biochemistry, Florida International University, Miami, Florida, United States of America

  ⨯