Metabolomic Analysis Reveals Metabolic Disturbance in the Cortex and Hippocampus of Subchronic MK-801 Treated Rats

Liya Sun; Juan Li; Kejun Zhou; Ming Zhang; Jinglei Yang; Yang Li; Baohu Ji; Zhao Zhang; Hui Zhu; Lun Yang; Guang He; Linghan Gao; Zhiyun Wei; Kejian Wang; Xue Han; Weiqing Liu; Liwen Tan; Yihua Yu; Lin He; Chunling Wan

doi:10.1371/journal.pone.0060598

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Peer-reviewed

Research Article

Metabolomic Analysis Reveals Metabolic Disturbance in the Cortex and Hippocampus of Subchronic MK-801 Treated Rats

Liya Sun,

Affiliations Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, People’s Republic of China, Institutes for Nutritional Sciences, Shanghai Institute of Biological Sciences, Chinese Academy of Sciences, Shanghai, People’s Republic of China
⨯
Juan Li,

Affiliations East China Normal University, Department of Physics, Shanghai, People’s Republic of China, CSIRO Animal, Food and Health Sciences, Queensland Bioscience Precinct, St. Lucia, Brisbane, Queensland, Australia
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Kejun Zhou,

Affiliations Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, People’s Republic of China, Institutes for Nutritional Sciences, Shanghai Institute of Biological Sciences, Chinese Academy of Sciences, Shanghai, People’s Republic of China
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Ming Zhang,

Affiliations Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, People’s Republic of China, Institutes for Nutritional Sciences, Shanghai Institute of Biological Sciences, Chinese Academy of Sciences, Shanghai, People’s Republic of China
⨯
Jinglei Yang,

Affiliations Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, People’s Republic of China, Institutes for Nutritional Sciences, Shanghai Institute of Biological Sciences, Chinese Academy of Sciences, Shanghai, People’s Republic of China
⨯
Yang Li,

Affiliations Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, People’s Republic of China, Institutes for Nutritional Sciences, Shanghai Institute of Biological Sciences, Chinese Academy of Sciences, Shanghai, People’s Republic of China
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Baohu Ji,

Affiliations Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, People’s Republic of China, Institutes for Nutritional Sciences, Shanghai Institute of Biological Sciences, Chinese Academy of Sciences, Shanghai, People’s Republic of China
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Zhao Zhang,

Affiliations Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, People’s Republic of China, Institutes for Nutritional Sciences, Shanghai Institute of Biological Sciences, Chinese Academy of Sciences, Shanghai, People’s Republic of China
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Hui Zhu,

Affiliations Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, People’s Republic of China, Institutes for Nutritional Sciences, Shanghai Institute of Biological Sciences, Chinese Academy of Sciences, Shanghai, People’s Republic of China
⨯
Lun Yang,

Affiliations Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, People’s Republic of China, Institutes for Nutritional Sciences, Shanghai Institute of Biological Sciences, Chinese Academy of Sciences, Shanghai, People’s Republic of China
⨯
Guang He,

Affiliations Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, People’s Republic of China, Institutes for Nutritional Sciences, Shanghai Institute of Biological Sciences, Chinese Academy of Sciences, Shanghai, People’s Republic of China
⨯
Linghan Gao,

Affiliations Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, People’s Republic of China, Institutes for Nutritional Sciences, Shanghai Institute of Biological Sciences, Chinese Academy of Sciences, Shanghai, People’s Republic of China
⨯
Zhiyun Wei,

Affiliations Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, People’s Republic of China, Institutes for Nutritional Sciences, Shanghai Institute of Biological Sciences, Chinese Academy of Sciences, Shanghai, People’s Republic of China
⨯
Kejian Wang,

Affiliations Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, People’s Republic of China, Institutes for Nutritional Sciences, Shanghai Institute of Biological Sciences, Chinese Academy of Sciences, Shanghai, People’s Republic of China
⨯
Xue Han,

Affiliation Second Xiangya Hospital, Central South University, Institute of Mental Health, Changsha, People’s Republic of China
⨯
Weiqing Liu,

Affiliation Second Xiangya Hospital, Central South University, Institute of Mental Health, Changsha, People’s Republic of China
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Liwen Tan,

Affiliation Second Xiangya Hospital, Central South University, Institute of Mental Health, Changsha, People’s Republic of China
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Yihua Yu ,

* E-mail: yhyu@phy.ecnu.edu.cn (YY); helin@bio-x.cn (LH); clwan@sjtu.edu.cn (CW)

Affiliation East China Normal University, Department of Physics, Shanghai, People’s Republic of China
⨯
Lin He ,

* E-mail: yhyu@phy.ecnu.edu.cn (YY); helin@bio-x.cn (LH); clwan@sjtu.edu.cn (CW)

Affiliations Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, People’s Republic of China, Institutes for Nutritional Sciences, Shanghai Institute of Biological Sciences, Chinese Academy of Sciences, Shanghai, People’s Republic of China
⨯
[ ... ],
Chunling Wan

* E-mail: yhyu@phy.ecnu.edu.cn (YY); helin@bio-x.cn (LH); clwan@sjtu.edu.cn (CW)

Affiliations Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, People’s Republic of China, Institutes for Nutritional Sciences, Shanghai Institute of Biological Sciences, Chinese Academy of Sciences, Shanghai, People’s Republic of China
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Metabolomic Analysis Reveals Metabolic Disturbance in the Cortex and Hippocampus of Subchronic MK-801 Treated Rats

Liya Sun,
Juan Li,
Kejun Zhou,
Ming Zhang,
Jinglei Yang,
Yang Li,
Baohu Ji,
Zhao Zhang,
Hui Zhu,
Lun Yang

Published: April 5, 2013
https://doi.org/10.1371/journal.pone.0060598

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