Pharmacometabolomic Approach to Predict QT Prolongation in Guinea Pigs

Jeonghyeon Park; Keumhan Noh; Hae Won Lee; Mi-sun Lim; Sook Jin Seong; Jeong Ju Seo; Eun-Jung Kim; Wonku Kang; Young-Ran Yoon

doi:10.1371/journal.pone.0060556

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Open Access

Peer-reviewed

Research Article

Pharmacometabolomic Approach to Predict QT Prolongation in Guinea Pigs

Jeonghyeon Park ,

Contributed equally to this work with: Jeonghyeon Park, Keumhan Noh

Affiliations Department of Molecular Medicine, Kyungpook National University School of Medicine and BK21 program, Kyungpook National University School of Medicine, Daegu, South Korea, Clinical Trial Center, Kyungpook National University Hospital, Daegu, South Korea
⨯
Keumhan Noh ,

Contributed equally to this work with: Jeonghyeon Park, Keumhan Noh

Affiliation College of Pharmacy, Yeungnam University, Kyoungbuk, South Korea
⨯
Hae Won Lee,

Affiliation Clinical Trial Center, Kyungpook National University Hospital, Daegu, South Korea
⨯
Mi-sun Lim,

Affiliation Clinical Trial Center, Kyungpook National University Hospital, Daegu, South Korea
⨯
Sook Jin Seong,

Affiliations Department of Molecular Medicine, Kyungpook National University School of Medicine and BK21 program, Kyungpook National University School of Medicine, Daegu, South Korea, Clinical Trial Center, Kyungpook National University Hospital, Daegu, South Korea
⨯
Jeong Ju Seo,

Affiliations Department of Molecular Medicine, Kyungpook National University School of Medicine and BK21 program, Kyungpook National University School of Medicine, Daegu, South Korea, Clinical Trial Center, Kyungpook National University Hospital, Daegu, South Korea
⨯
Eun-Jung Kim,

Affiliation National Institute of Food and Drug Safety Evaluation, Korea Food and Drug Administration, Chungbuk, South Korea
⨯
Wonku Kang ,

* E-mail: wonkuk@yu.ac.kr (WK); yry@knu.ac.kr (YRY)

Affiliation College of Pharmacy, Yeungnam University, Kyoungbuk, South Korea
⨯
Young-Ran Yoon

* E-mail: wonkuk@yu.ac.kr (WK); yry@knu.ac.kr (YRY)

Affiliations Department of Molecular Medicine, Kyungpook National University School of Medicine and BK21 program, Kyungpook National University School of Medicine, Daegu, South Korea, Clinical Trial Center, Kyungpook National University Hospital, Daegu, South Korea
⨯

Pharmacometabolomic Approach to Predict QT Prolongation in Guinea Pigs

Jeonghyeon Park,
Keumhan Noh,
Hae Won Lee,
Mi-sun Lim,
Sook Jin Seong,
Jeong Ju Seo,
Eun-Jung Kim,
Wonku Kang,
Young-Ran Yoon

Published: April 4, 2013
https://doi.org/10.1371/journal.pone.0060556

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