Pro-Asthmatic Cytokines Regulate Unliganded and Ligand-Dependent Glucocorticoid Receptor Signaling in Airway Smooth Muscle

Aihua Hu; Maureen B. Josephson; Barry L. Diener; Gustavo Nino; Shuyun Xu; Chinmay Paranjape; Jordan S. Orange; Michael M. Grunstein

doi:10.1371/journal.pone.0060452

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Peer-reviewed

Research Article

Pro-Asthmatic Cytokines Regulate Unliganded and Ligand-Dependent Glucocorticoid Receptor Signaling in Airway Smooth Muscle

Aihua Hu,

Affiliation Division of Pulmonary Medicine, Children's Hospital of Philadelphia Research Institute, University of Pennsylvania Perlman School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Maureen B. Josephson,

Affiliation Division of Pulmonary Medicine, Children's Hospital of Philadelphia Research Institute, University of Pennsylvania Perlman School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Barry L. Diener,

Affiliation Division of Pulmonary Medicine, Children's Hospital of Philadelphia Research Institute, University of Pennsylvania Perlman School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Gustavo Nino,

Affiliations Division of Pulmonary Medicine, Children's Hospital of Philadelphia Research Institute, University of Pennsylvania Perlman School of Medicine, Philadelphia, Pennsylvania, United States of America, Department of Integrative Systems Biology and Division of Pulmonary & Sleep Medicine, Children's National Medical Center, Center for Genetic Medicine Research, George Washington University, Washington, D.C., United States of America
⨯
Shuyun Xu,

Affiliation Division of Pulmonary Medicine, Children's Hospital of Philadelphia Research Institute, University of Pennsylvania Perlman School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Chinmay Paranjape,

Affiliation Division of Pulmonary Medicine, Children's Hospital of Philadelphia Research Institute, University of Pennsylvania Perlman School of Medicine, Philadelphia, Pennsylvania, United States of America
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Jordan S. Orange,

Affiliation Section of Immunology, Allergy and Rheumatology, Texas Children's Hospital, Baylor College of Medicine, Houston, Texas, United States of America
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Michael M. Grunstein

* E-mail: grunstein@email.chop.edu

Affiliation Division of Pulmonary Medicine, Children's Hospital of Philadelphia Research Institute, University of Pennsylvania Perlman School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯

Pro-Asthmatic Cytokines Regulate Unliganded and Ligand-Dependent Glucocorticoid Receptor Signaling in Airway Smooth Muscle

Aihua Hu,
Maureen B. Josephson,
Barry L. Diener,
Gustavo Nino,
Shuyun Xu,
Chinmay Paranjape,
Jordan S. Orange,
Michael M. Grunstein

Published: April 4, 2013
https://doi.org/10.1371/journal.pone.0060452

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