RNA Interference against Platelet-Derived Growth Factor Receptor α mRNA Inhibits Fibroblast Transdifferentiation in Skin Lesions of Patients with Systemic Sclerosis

Tong Liu; Jian Zhang; Jing Zhang; Xin Mu; Hui Su; Xiaoding Hu; Wenli Liu; Enbing Zhao; Weimin Li

doi:10.1371/journal.pone.0060414

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Open Access

Peer-reviewed

Research Article

RNA Interference against Platelet-Derived Growth Factor Receptor α mRNA Inhibits Fibroblast Transdifferentiation in Skin Lesions of Patients with Systemic Sclerosis

Tong Liu ,

Contributed equally to this work with: Tong Liu, Jian Zhang

* E-mail: tonyl1220@sina.com

Affiliation Department of Dermatology, First Affiliated Hospital, College of Medicine, Xi’an Jiaotong University, Xìan City, Shaanxi Province, China
⨯
Jian Zhang ,

Contributed equally to this work with: Tong Liu, Jian Zhang

Affiliation Department of Dermatology, First Affiliated Hospital, College of Medicine, Xi’an Jiaotong University, Xìan City, Shaanxi Province, China
⨯
Jing Zhang,

Affiliation Department of Dermatology, First Affiliated Hospital, College of Medicine, Xi’an Jiaotong University, Xìan City, Shaanxi Province, China
⨯
Xin Mu,

Affiliation Department of Dermatology, First Affiliated Hospital, College of Medicine, Xi’an Jiaotong University, Xìan City, Shaanxi Province, China
⨯
Hui Su,

Affiliation Department of Dermatology, Second Affiliated Hospital, College of Medicine, Xi’an Jiaotong University, Xìan City, Shaanxi Province, China
⨯
Xiaoding Hu,

Affiliation Department of Dermatology, First Affiliated Hospital, College of Medicine, Xi’an Jiaotong University, Xìan City, Shaanxi Province, China
⨯
Wenli Liu,

Affiliation Department of Dermatology, First Affiliated Hospital, College of Medicine, Xi’an Jiaotong University, Xìan City, Shaanxi Province, China
⨯
Enbing Zhao,

Affiliation Department of Dermatology, First Affiliated Hospital, College of Medicine, Xi’an Jiaotong University, Xìan City, Shaanxi Province, China
⨯
Weimin Li

Affiliation Department of Dermatology, First Affiliated Hospital, College of Medicine, Xi’an Jiaotong University, Xìan City, Shaanxi Province, China
⨯

RNA Interference against Platelet-Derived Growth Factor Receptor α mRNA Inhibits Fibroblast Transdifferentiation in Skin Lesions of Patients with Systemic Sclerosis

Tong Liu,
Jian Zhang,
Jing Zhang,
Xin Mu,
Hui Su,
Xiaoding Hu,
Wenli Liu,
Enbing Zhao,
Weimin Li

Published: April 5, 2013
https://doi.org/10.1371/journal.pone.0060414

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Fibroblasts
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Small interfering RNA
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Protein expression
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Lesions
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Transdifferentiation
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Transfection
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Messenger RNA
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Cultured fibroblasts
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