Gene Expression Variability in Human Hepatic Drug Metabolizing Enzymes and Transporters

Lun Yang; Elvin T. Price; Ching-Wei Chang; Yan Li; Ying Huang; Li-Wu Guo; Yongli Guo; Jim Kaput; Leming Shi; Baitang Ning

doi:10.1371/journal.pone.0060368

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Open Access

Peer-reviewed

Research Article

Gene Expression Variability in Human Hepatic Drug Metabolizing Enzymes and Transporters

Lun Yang,

Current address: GlaxoSmithKline, Philadelphia, Pennsylvania, United States of America

Affiliation Division of Systems Biology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas, United States of America
⨯
Elvin T. Price,

Affiliation Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America
⨯
Ching-Wei Chang,

Affiliation Division of Systems Biology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas, United States of America
⨯
Yan Li,

Affiliation Division of Systems Biology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas, United States of America
⨯
Ying Huang,

Affiliation Department of Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, Pomona, California, United States of America
⨯
Li-Wu Guo,

Affiliation Division of Systems Biology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas, United States of America
⨯
Yongli Guo,

Affiliation Division of Systems Biology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas, United States of America
⨯
Jim Kaput,

Current address: Nestle Institute of Health Sciences, Lausanne, Switzerland

Affiliation Division of Systems Biology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas, United States of America
⨯
Leming Shi ,

* E-mail: baitang.ning@fda.hhs.gov (BN); leming.shi@fda.hhs.gov (LS)

Affiliation Division of Systems Biology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas, United States of America
⨯
Baitang Ning

* E-mail: baitang.ning@fda.hhs.gov (BN); leming.shi@fda.hhs.gov (LS)

Affiliation Division of Systems Biology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas, United States of America
⨯

Gene Expression Variability in Human Hepatic Drug Metabolizing Enzymes and Transporters

Lun Yang,
Elvin T. Price,
Ching-Wei Chang,
Yan Li,
Ying Huang,
Li-Wu Guo,
Yongli Guo,
Jim Kaput,
Leming Shi,
Baitang Ning

Published: April 23, 2013
https://doi.org/10.1371/journal.pone.0060368

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Gene expression
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Drug metabolism
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Hepatocellular carcinoma
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