Replication-Competent Infectious Hepatitis B Virus Vectors Carrying Substantially Sized Transgenes by Redesigned Viral Polymerase Translation

Zihua Wang; Li Wu; Xin Cheng; Shizhu Liu; Baosheng Li; Haijun Li; Fubiao Kang; Junping Wang; Huan Xia; Caiyan Ping; Michael Nassal; Dianxing Sun

doi:10.1371/journal.pone.0060306

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Peer-reviewed

Research Article

Replication-Competent Infectious Hepatitis B Virus Vectors Carrying Substantially Sized Transgenes by Redesigned Viral Polymerase Translation

Zihua Wang ,

Contributed equally to this work with: Zihua Wang, Li Wu, Xin Cheng

Affiliations The Liver Disease Diagnosis and Treatment Center of PLA, Bethune International Peace Hospital, Shijiazhuang, PR China, The Third Military Medical University, Chongqing, PR China
⨯
Li Wu ,

Contributed equally to this work with: Zihua Wang, Li Wu, Xin Cheng

Current address: The Second Department of Baoding Infectious Disease Hospital, Baoding, PR China

Affiliation The Liver Disease Diagnosis and Treatment Center of PLA, Bethune International Peace Hospital, Shijiazhuang, PR China
⨯
Xin Cheng ,

Contributed equally to this work with: Zihua Wang, Li Wu, Xin Cheng

Affiliation The Liver Disease Diagnosis and Treatment Center of PLA, Bethune International Peace Hospital, Shijiazhuang, PR China
⨯
Shizhu Liu,

Affiliation The Liver Disease Diagnosis and Treatment Center of PLA, Bethune International Peace Hospital, Shijiazhuang, PR China
⨯
Baosheng Li,

Affiliation The Liver Disease Diagnosis and Treatment Center of PLA, Bethune International Peace Hospital, Shijiazhuang, PR China
⨯
Haijun Li,

Affiliation The Liver Disease Diagnosis and Treatment Center of PLA, Bethune International Peace Hospital, Shijiazhuang, PR China
⨯
Fubiao Kang,

Affiliation The Liver Disease Diagnosis and Treatment Center of PLA, Bethune International Peace Hospital, Shijiazhuang, PR China
⨯
Junping Wang,

Affiliation The Liver Disease Diagnosis and Treatment Center of PLA, Bethune International Peace Hospital, Shijiazhuang, PR China
⨯
Huan Xia,

Affiliation The Liver Disease Diagnosis and Treatment Center of PLA, Bethune International Peace Hospital, Shijiazhuang, PR China
⨯
Caiyan Ping,

Affiliation The Liver Disease Diagnosis and Treatment Center of PLA, Bethune International Peace Hospital, Shijiazhuang, PR China
⨯
Michael Nassal ,

* E-mail: sundianxing@hotmail.com (DS); nassal2@ukl.uni-freiburg.de (MN)

Affiliation University Hospital Freiburg, Internal Medicine II/Molecular Biology, Freiburg, Germany
⨯
Dianxing Sun

* E-mail: sundianxing@hotmail.com (DS); nassal2@ukl.uni-freiburg.de (MN)

Affiliation The Liver Disease Diagnosis and Treatment Center of PLA, Bethune International Peace Hospital, Shijiazhuang, PR China
⨯

Replication-Competent Infectious Hepatitis B Virus Vectors Carrying Substantially Sized Transgenes by Redesigned Viral Polymerase Translation

Zihua Wang,
Li Wu,
Xin Cheng,
Shizhu Liu,
Baosheng Li,
Haijun Li,
Fubiao Kang,
Junping Wang,
Huan Xia,
Caiyan Ping

Published: April 2, 2013
https://doi.org/10.1371/journal.pone.0060306

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