Re-Directing an Alkylating Agent to Mitochondria Alters Drug Target and Cell Death Mechanism

• Rida Mourtada ,

  Contributed equally to this work with: Rida Mourtada, Sonali B. Fonseca

  Affiliation Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada

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• Sonali B. Fonseca ,

  Contributed equally to this work with: Rida Mourtada, Sonali B. Fonseca

  Affiliation Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada

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• Simon P. Wisnovsky,

  Affiliation Department of Biochemistry, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada

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• Mark P. Pereira,

  Affiliation Department of Biochemistry, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada

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• Xiaoming Wang,

  Affiliation Princess Margaret Hospital, Ontario Cancer Institute, Campbell Family Cancer Research Institute, Toronto, Ontario, Canada

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• Rose Hurren,

  Affiliation Princess Margaret Hospital, Ontario Cancer Institute, Campbell Family Cancer Research Institute, Toronto, Ontario, Canada

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• Jeremy Parfitt,

  Affiliation Department of Pathology, University of Western Ontario, London, Ontario, Canada

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• Lesley Larsen,

  Affiliation Department of Chemistry, University of Otago, Dunedin, New Zealand

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• Robin A. J. Smith,

  Affiliation Department of Chemistry, University of Otago, Dunedin, New Zealand

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• Michael P. Murphy,

  Affiliation Medical Research Council Mitochondrial Biology Unit, Wellcome Trust/Medical Research Council Building, Cambridge, United Kingdom

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• Aaron D. Schimmer,

  Affiliation Princess Margaret Hospital, Ontario Cancer Institute, Campbell Family Cancer Research Institute, Toronto, Ontario, Canada

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• Shana O. Kelley

  * E-mail: shana.kelley@utoronto.ca

  Affiliations Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada, Department of Biochemistry, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada

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