Population-Based Input Function Modeling for [18F]FMPEP-d2, an Inverse Agonist Radioligand for Cannabinoid CB1 Receptors: Validation in Clinical Studies

Paolo Zanotti-Fregonara; Jussi Hirvonen; Chul Hyoung Lyoo; Sami S. Zoghbi; Denise Rallis-Frutos; Marilyn A. Huestis; Cheryl Morse; Victor W. Pike; Robert B. Innis

doi:10.1371/journal.pone.0060231

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Peer-reviewed

Research Article

Population-Based Input Function Modeling for [¹⁸F]FMPEP-d₂, an Inverse Agonist Radioligand for Cannabinoid CB₁ Receptors: Validation in Clinical Studies

Paolo Zanotti-Fregonara,

Affiliation Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Jussi Hirvonen,

Affiliation Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Chul Hyoung Lyoo,

Affiliation Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Sami S. Zoghbi,

Affiliation Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Denise Rallis-Frutos,

Affiliation Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Marilyn A. Huestis,

Affiliation Chemistry and Drug Metabolism Section, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland, United States of America
⨯
Cheryl Morse,

Affiliation Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Victor W. Pike,

Affiliation Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Robert B. Innis

* E-mail: robert.innis@nih.gov

Affiliation Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, United States of America
⨯

Population-Based Input Function Modeling for [¹⁸F]FMPEP-d₂, an Inverse Agonist Radioligand for Cannabinoid CB₁ Receptors: Validation in Clinical Studies

Paolo Zanotti-Fregonara,
Jussi Hirvonen,
Chul Hyoung Lyoo,
Sami S. Zoghbi,
Denise Rallis-Frutos,
Marilyn A. Huestis,
Cheryl Morse,
Victor W. Pike,
Robert B. Innis

Published: April 5, 2013
https://doi.org/10.1371/journal.pone.0060231

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