Tumor Necrosis Factor-α and Lymphotoxin-α Mediate Myocardial Ischemic Injury via TNF Receptor 1, but Are Cardioprotective When Activating TNF Receptor 2

Yanqing Zhang; Jianli Zhao; Wayne Bond Lau; Li-Yuan Jiao; Baojiang Liu; Yuexing Yuan; Xiaoliang Wang; Erhe Gao; Walter J. Koch; Xin-Liang Ma; Yajing Wang

doi:10.1371/journal.pone.0060227

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Open Access

Peer-reviewed

Research Article

Tumor Necrosis Factor-α and Lymphotoxin-α Mediate Myocardial Ischemic Injury via TNF Receptor 1, but Are Cardioprotective When Activating TNF Receptor 2

Yanqing Zhang ,

Contributed equally to this work with: Yanqing Zhang, Jianli Zhao

Affiliation Department of Anesthesiology, First Affiliated Hospital, Shanxi Medical University, Taiyuan, China
⨯
Jianli Zhao ,

Contributed equally to this work with: Yanqing Zhang, Jianli Zhao

Affiliation Department of Anesthesiology, First Affiliated Hospital, Shanxi Medical University, Taiyuan, China
⨯
Wayne Bond Lau,

Affiliation Department of Emergency Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America
⨯
Li-Yuan Jiao,

Affiliation Department of Anesthesiology, First Affiliated Hospital, Shanxi Medical University, Taiyuan, China
⨯
Baojiang Liu,

Affiliation Department of Anesthesiology, First Affiliated Hospital, Shanxi Medical University, Taiyuan, China
⨯
Yuexing Yuan,

Affiliation Department of Emergency Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America
⨯
Xiaoliang Wang,

Affiliations Department of Emergency Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America, Department of Physiology, Shanxi Medical University, Taiyuan, China
⨯
Erhe Gao,

Affiliation Center for Translational Medicine, Temple University Medical School, Philadelphia, Pennsylvania, United States of America
⨯
Walter J. Koch,

Affiliation Center for Translational Medicine, Temple University Medical School, Philadelphia, Pennsylvania, United States of America
⨯
Xin-Liang Ma ,

* E-mail: Yajing.Wang@jefferson.edu (YW); Xin.Ma@Jefferson.edu (XLM)

Affiliation Department of Emergency Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America
⨯
Yajing Wang

* E-mail: Yajing.Wang@jefferson.edu (YW); Xin.Ma@Jefferson.edu (XLM)

Affiliations Department of Emergency Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America, Department of Physiology, Shanxi Medical University, Taiyuan, China
⨯

Tumor Necrosis Factor-α and Lymphotoxin-α Mediate Myocardial Ischemic Injury via TNF Receptor 1, but Are Cardioprotective When Activating TNF Receptor 2

Yanqing Zhang,
Jianli Zhao,
Wayne Bond Lau,
Li-Yuan Jiao,
Baojiang Liu,
Yuexing Yuan,
Xiaoliang Wang,
Erhe Gao,
Walter J. Koch,
Xin-Liang Ma

Published: May 21, 2013
https://doi.org/10.1371/journal.pone.0060227

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