P2X7 Integrates PI3K/AKT and AMPK-PRAS40-mTOR Signaling Pathways to Mediate Tumor Cell Death

Shu Bian; Xiaofeng Sun; Aiping Bai; Chunqing Zhang; Linglin Li; Keiichi Enjyoji; Wolfgang G. Junger; Simon C. Robson; Yan Wu

doi:10.1371/journal.pone.0060184

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Peer-reviewed

Research Article

P2X7 Integrates PI3K/AKT and AMPK-PRAS40-mTOR Signaling Pathways to Mediate Tumor Cell Death

Shu Bian ,

Contributed equally to this work with: Shu Bian, Xiaofeng Sun

Affiliations Department of Gastroenterology, Provincial Hospital Affiliated to Shandong University, Jinan, People’s Republic of China, Department of Medicine, Transplant Institute, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Xiaofeng Sun ,

Contributed equally to this work with: Shu Bian, Xiaofeng Sun

Affiliation Department of Medicine, Transplant Institute, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Aiping Bai,

Affiliation Department of Medicine, Transplant Institute, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Chunqing Zhang,

Affiliation Department of Gastroenterology, Provincial Hospital Affiliated to Shandong University, Jinan, People’s Republic of China
⨯
Linglin Li,

Affiliation Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Keiichi Enjyoji,

Affiliation Department of Medicine, Transplant Institute, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Wolfgang G. Junger,

Affiliation Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Simon C. Robson ,

* E-mail: ywu@bidmc.harvard.edu (YW); srobson@bidmc.harvard.edu (SCR)

Affiliation Department of Medicine, Transplant Institute, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Yan Wu

* E-mail: ywu@bidmc.harvard.edu (YW); srobson@bidmc.harvard.edu (SCR)

Affiliation Department of Medicine, Transplant Institute, Harvard Medical School, Boston, Massachusetts, United States of America
⨯

P2X7 Integrates PI3K/AKT and AMPK-PRAS40-mTOR Signaling Pathways to Mediate Tumor Cell Death

Shu Bian,
Xiaofeng Sun,
Aiping Bai,
Chunqing Zhang,
Linglin Li,
Keiichi Enjyoji,
Wolfgang G. Junger,
Simon C. Robson,
Yan Wu

Published: April 2, 2013
https://doi.org/10.1371/journal.pone.0060184

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