Inhibition of PIKfyve by YM-201636 Dysregulates Autophagy and Leads to Apoptosis-Independent Neuronal Cell Death

Open Access

Peer-reviewed

Research Article

Sally Martin ,

Contributed equally to this work with: Sally Martin, Callista B. Harper

Affiliation The University of Queensland, Queensland Brain Institute, Brisbane, Queensland, Australia
⨯
Callista B. Harper ,

Contributed equally to this work with: Sally Martin, Callista B. Harper

Affiliation The University of Queensland, Queensland Brain Institute, Brisbane, Queensland, Australia
⨯
Linda M. May,

Affiliation The University of Queensland, Queensland Brain Institute, Brisbane, Queensland, Australia
⨯
Elizabeth J. Coulson,

Affiliation The University of Queensland, Queensland Brain Institute, Brisbane, Queensland, Australia
⨯
Frederic A. Meunier ,

* E-mail: f.meunier@uq.edu.au (FAM); s.osborne@uq.edu.au (SLO)

Affiliation The University of Queensland, Queensland Brain Institute, Brisbane, Queensland, Australia
⨯
Shona L. Osborne

* E-mail: f.meunier@uq.edu.au (FAM); s.osborne@uq.edu.au (SLO)

Affiliation The University of Queensland, Queensland Brain Institute, Brisbane, Queensland, Australia
⨯

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Neuronal death
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Neurons
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Hippocampus
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Autophagic cell death
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Vacuoles
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Apoptosis
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Lysosomes
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Neurites
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