Glycogen Synthase Kinase-3 Inhibition Enhances Translation of Pluripotency-Associated Transcription Factors to Contribute to Maintenance of Mouse Embryonic Stem Cell Self-Renewal

Yolanda Sanchez-Ripoll; Heather K. Bone; Tom Owen; Ana M. V. Guedes; Elsa Abranches; Benjamin Kumpfmueller; Ruth V. Spriggs; Domingos Henrique; Melanie J. Welham

doi:10.1371/journal.pone.0060148

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Peer-reviewed

Research Article

Glycogen Synthase Kinase-3 Inhibition Enhances Translation of Pluripotency-Associated Transcription Factors to Contribute to Maintenance of Mouse Embryonic Stem Cell Self-Renewal

Yolanda Sanchez-Ripoll,

Current address: Spanish National Cancer Research Centre, Madrid, Spain

Affiliation Centre for Regenerative Medicine and Department of Pharmacy & Pharmacology, University of Bath, Bath, United Kingdom
⨯
Heather K. Bone,

Affiliation Centre for Regenerative Medicine and Department of Pharmacy & Pharmacology, University of Bath, Bath, United Kingdom
⨯
Tom Owen,

Affiliation Centre for Regenerative Medicine and Department of Pharmacy & Pharmacology, University of Bath, Bath, United Kingdom
⨯
Ana M. V. Guedes,

Affiliation Instituto Medicina Molecular, and Instituto de Histologia e Biologia do Desenvolvimento, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal
⨯
Elsa Abranches,

Affiliation Instituto Medicina Molecular, and Instituto de Histologia e Biologia do Desenvolvimento, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal
⨯
Benjamin Kumpfmueller,

Current address: Spanish National Cancer Research Centre, Madrid, Spain

Affiliation Centre for Regenerative Medicine and Department of Pharmacy & Pharmacology, University of Bath, Bath, United Kingdom
⨯
Ruth V. Spriggs,

Affiliation Medical Research Centre Toxicology Unit, University of Leicester, Hodgkin Building, Leicester, United Kingdom
⨯
Domingos Henrique,

Affiliation Instituto Medicina Molecular, and Instituto de Histologia e Biologia do Desenvolvimento, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal
⨯
Melanie J. Welham

* E-mail: M.J.Welham@bath.ac.uk

Current address: Biotechnology and Biological Sciences Research Council, Polaris House, Swindon, United Kingdom

Affiliation Centre for Regenerative Medicine and Department of Pharmacy & Pharmacology, University of Bath, Bath, United Kingdom
⨯

Glycogen Synthase Kinase-3 Inhibition Enhances Translation of Pluripotency-Associated Transcription Factors to Contribute to Maintenance of Mouse Embryonic Stem Cell Self-Renewal

Yolanda Sanchez-Ripoll,
Heather K. Bone,
Tom Owen,
Ana M. V. Guedes,
Elsa Abranches,
Benjamin Kumpfmueller,
Ruth V. Spriggs,
Domingos Henrique,
Melanie J. Welham

Published: April 5, 2013
https://doi.org/10.1371/journal.pone.0060148

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Pluripotency
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Transcription factors
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Protein translation
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Transcriptional control
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Phosphorylation
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Protein synthesis
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Gene expression
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Polyribosomes
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