Computational Evolutionary Analysis of the Overlapped Surface (S) and Polymerase (P) Region in Hepatitis B Virus Indicates the Spacer Domain in P Is Crucial for Survival

• Ping Chen,

  Affiliations Key Laboratory of Agricultural and Environmental Microbiology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China, State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China

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• Yun Gan,

  Affiliation State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China

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• Na Han,

  Affiliation Key Laboratory of Agricultural and Environmental Microbiology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China

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• Wei Fang,

  Affiliation Key Laboratory of Agricultural and Environmental Microbiology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China

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• Jiafu Li,

  Affiliation Department of Obstetrics and Gynecology, Zhongnan Hospital of Wuhan University, Wuhan, China

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• Fei Zhao,

  Affiliation State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China

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• Kanghong Hu ,

  * E-mail: s.raynere@wh.iov.cn (SR); hukgh@wh.iov.cn (KH)

  Affiliations State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China, Biomedical Center, Hubei University of Technology, Wuhan, China

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• Simon Rayner

  * E-mail: s.raynere@wh.iov.cn (SR); hukgh@wh.iov.cn (KH)

  Affiliation Key Laboratory of Agricultural and Environmental Microbiology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China

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