Dectin-1 Regulates IL-10 Production via a MSK1/2 and CREB Dependent Pathway and Promotes the Induction of Regulatory Macrophage Markers

Suzanne E. Elcombe; Shaista Naqvi; Mirjam W. M. Van Den Bosch; Kirsty F. MacKenzie; Francesca Cianfanelli; Gordon D. Brown; J. Simon C. Arthur

doi:10.1371/journal.pone.0060086

Loading metrics

Open Access

Peer-reviewed

Research Article

Dectin-1 Regulates IL-10 Production via a MSK1/2 and CREB Dependent Pathway and Promotes the Induction of Regulatory Macrophage Markers

Suzanne E. Elcombe,

Affiliation MRC Protein Phosphorylation Unit, College of Life Sciences, Sir James Black Complex, The University of Dundee, Dundee, Scotland, United Kingdom
⨯
Shaista Naqvi,

Affiliations MRC Protein Phosphorylation Unit, College of Life Sciences, Sir James Black Complex, The University of Dundee, Dundee, Scotland, United Kingdom, Division of Cell Signaling and Immunology, College of Life Sciences, Sir James Black Complex, The University of Dundee, Dundee, Scotland, United Kingdom
⨯
Mirjam W. M. Van Den Bosch,

Affiliation MRC Protein Phosphorylation Unit, College of Life Sciences, Sir James Black Complex, The University of Dundee, Dundee, Scotland, United Kingdom
⨯
Kirsty F. MacKenzie,

Affiliations MRC Protein Phosphorylation Unit, College of Life Sciences, Sir James Black Complex, The University of Dundee, Dundee, Scotland, United Kingdom, Division of Cell Signaling and Immunology, College of Life Sciences, Sir James Black Complex, The University of Dundee, Dundee, Scotland, United Kingdom
⨯
Francesca Cianfanelli,

Affiliation Division of Cell Signaling and Immunology, College of Life Sciences, Sir James Black Complex, The University of Dundee, Dundee, Scotland, United Kingdom
⨯
Gordon D. Brown,

Affiliation Section of Infection and Immunity, Institute of Molecular Sciences, School of Medicine and Dentistry, University of Aberdeen, Aberdeen, United Kingdom
⨯
J. Simon C. Arthur

* E-mail: j.s.c.arthur@dundee.ac.uk

Affiliations MRC Protein Phosphorylation Unit, College of Life Sciences, Sir James Black Complex, The University of Dundee, Dundee, Scotland, United Kingdom, Division of Cell Signaling and Immunology, College of Life Sciences, Sir James Black Complex, The University of Dundee, Dundee, Scotland, United Kingdom
⨯

Dectin-1 Regulates IL-10 Production via a MSK1/2 and CREB Dependent Pathway and Promotes the Induction of Regulatory Macrophage Markers

Suzanne E. Elcombe,
Shaista Naqvi,
Mirjam W. M. Van Den Bosch,
Kirsty F. MacKenzie,
Francesca Cianfanelli,
Gordon D. Brown,
J. Simon C. Arthur

Published: March 22, 2013
https://doi.org/10.1371/journal.pone.0060086

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Macrophages
Is the Subject Area "Macrophages" applicable to this article?

Thanks for your feedback.
Phosphorylation
Is the Subject Area "Phosphorylation" applicable to this article?

Thanks for your feedback.
Messenger RNA
Is the Subject Area "Messenger RNA" applicable to this article?

Thanks for your feedback.
MAPK signaling cascades
Is the Subject Area "MAPK signaling cascades" applicable to this article?

Thanks for your feedback.
Secretion
Is the Subject Area "Secretion" applicable to this article?

Thanks for your feedback.
Genetically modified animals
Is the Subject Area "Genetically modified animals" applicable to this article?

Thanks for your feedback.
Transcriptional control
Is the Subject Area "Transcriptional control" applicable to this article?

Thanks for your feedback.
Cytokines
Is the Subject Area "Cytokines" applicable to this article?

Thanks for your feedback.