Co-Stimulation through 4-1BB/CD137 Improves the Expansion and Function of CD8+ Melanoma Tumor-Infiltrating Lymphocytes for Adoptive T-Cell Therapy

Jessica Ann Chacon; Richard C. Wu; Pariya Sukhumalchandra; Jeffrey J. Molldrem; Amod Sarnaik; Shari Pilon-Thomas; Jeffrey Weber; Patrick Hwu; Laszlo Radvanyi

doi:10.1371/journal.pone.0060031

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Peer-reviewed

Research Article

Co-Stimulation through 4-1BB/CD137 Improves the Expansion and Function of CD8⁺ Melanoma Tumor-Infiltrating Lymphocytes for Adoptive T-Cell Therapy

Jessica Ann Chacon,

Affiliations Department of Melanoma Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States of America, The Immunology Program of the University of Texas Health Science Center, Graduate School of Biomedical Sciences, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States of America
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Richard C. Wu,

Affiliations Department of Melanoma Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States of America, The Immunology Program of the University of Texas Health Science Center, Graduate School of Biomedical Sciences, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States of America
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Pariya Sukhumalchandra,

Affiliation Department of Stem Cell Transplantation, University of Texas, M. D. Anderson Cancer Center, Houston, Texas, United States of America
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Jeffrey J. Molldrem,

Affiliations The Immunology Program of the University of Texas Health Science Center, Graduate School of Biomedical Sciences, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States of America, Department of Stem Cell Transplantation, University of Texas, M. D. Anderson Cancer Center, Houston, Texas, United States of America
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Amod Sarnaik,

Affiliation Donald A. Adam Comprehensive Melanoma Research Center, Moffitt Cancer Center, Tampa, Florida, United States of America
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Shari Pilon-Thomas,

Affiliation Donald A. Adam Comprehensive Melanoma Research Center, Moffitt Cancer Center, Tampa, Florida, United States of America
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Jeffrey Weber,

Affiliation Donald A. Adam Comprehensive Melanoma Research Center, Moffitt Cancer Center, Tampa, Florida, United States of America
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Patrick Hwu,

Affiliations Department of Melanoma Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States of America, The Immunology Program of the University of Texas Health Science Center, Graduate School of Biomedical Sciences, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States of America
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Laszlo Radvanyi

* E-mail: lradvanyi@mdanderson.org

Affiliations Department of Melanoma Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States of America, The Immunology Program of the University of Texas Health Science Center, Graduate School of Biomedical Sciences, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States of America
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Co-Stimulation through 4-1BB/CD137 Improves the Expansion and Function of CD8⁺ Melanoma Tumor-Infiltrating Lymphocytes for Adoptive T-Cell Therapy

Jessica Ann Chacon,
Richard C. Wu,
Pariya Sukhumalchandra,
Jeffrey J. Molldrem,
Amod Sarnaik,
Shari Pilon-Thomas,
Jeffrey Weber,
Patrick Hwu,
Laszlo Radvanyi

Published: April 1, 2013
https://doi.org/10.1371/journal.pone.0060031

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