Mitochondrial DAMPs Increase Endothelial Permeability through Neutrophil Dependent and Independent Pathways

Shiqin Sun; Tolga Sursal; Yasaman Adibnia; Cong Zhao; Yi Zheng; Haipeng Li; Leo E. Otterbein; Carl J. Hauser; Kiyoshi Itagaki

doi:10.1371/journal.pone.0059989

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Peer-reviewed

Research Article

Mitochondrial DAMPs Increase Endothelial Permeability through Neutrophil Dependent and Independent Pathways

Shiqin Sun,

Current address: College of Pharmacy, Harbin Medical University-Daqing, Daqing, Heilongjiang Province, China

Affiliation Department of Surgery, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Tolga Sursal,

Current address: Eastern Virginia Medical School, Norfolk, Virginia, United States of America

Affiliation Department of Surgery, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Yasaman Adibnia,

Current address: Cerrahpasa Medical Faculty, Istanbul University, Cerrahpasa-Fatih, Istanbul, Turkey

Affiliation Department of Surgery, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Cong Zhao,

Affiliation Department of Surgery, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Yi Zheng,

Affiliation Department of Surgery, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Haipeng Li,

Affiliations Department of Surgery, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, Massachusetts, United States of America, Department of Orthopedic Surgery, Beijing Army General Hospital, Beijing, China
⨯
Leo E. Otterbein,

Affiliation Department of Surgery, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Carl J. Hauser ,

* E-mail: kitagaki@bidmc.harvard.edu (KI) (CH); cjhauser@bidmc.harvard.edu (CJH)

Affiliation Department of Surgery, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Kiyoshi Itagaki

* E-mail: kitagaki@bidmc.harvard.edu (KI) (CH); cjhauser@bidmc.harvard.edu (CJH)

Affiliation Department of Surgery, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, Massachusetts, United States of America
⨯

Mitochondrial DAMPs Increase Endothelial Permeability through Neutrophil Dependent and Independent Pathways

Shiqin Sun,
Tolga Sursal,
Yasaman Adibnia,
Cong Zhao,
Yi Zheng,
Haipeng Li,
Leo E. Otterbein,
Carl J. Hauser,
Kiyoshi Itagaki

Published: March 20, 2013
https://doi.org/10.1371/journal.pone.0059989

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Mitochondrial DNA
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Permeability
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Mitochondria
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Proteases
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Endothelial cells
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Inflammation
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Systemic inflammatory response syndrome
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Vascular permeability
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