ERG Induces Epigenetic Activation of Tudor Domain-Containing Protein 1 (TDRD1) in ERG Rearrangement-Positive Prostate Cancer

Lukasz A. Kacprzyk; Mark Laible; Tatjana Andrasiuk; Jan C. Brase; Stefan T. Börno; Maria Fälth; Ruprecht Kuner; Hans Lehrach; Michal R. Schweiger; Holger Sültmann

doi:10.1371/journal.pone.0059976

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Peer-reviewed

Research Article

ERG Induces Epigenetic Activation of Tudor Domain-Containing Protein 1 (TDRD1) in ERG Rearrangement-Positive Prostate Cancer

Lukasz A. Kacprzyk ,

Contributed equally to this work with: Lukasz A. Kacprzyk, Mark Laible

* E-mail: kacprzyk@ugabiopharma.com

Current address: UGA Biopharma GmbH, Hennigsdorf, Germany.

Affiliation Unit Cancer Genome Research, Division of Molecular Genetics, National Center for Tumor Diseases (NCT) and German Cancer Research Center (DKFZ), Heidelberg, Germany
⨯
Mark Laible ,

Contributed equally to this work with: Lukasz A. Kacprzyk, Mark Laible

Affiliation Unit Cancer Genome Research, Division of Molecular Genetics, National Center for Tumor Diseases (NCT) and German Cancer Research Center (DKFZ), Heidelberg, Germany
⨯
Tatjana Andrasiuk,

Affiliation Unit Cancer Genome Research, Division of Molecular Genetics, National Center for Tumor Diseases (NCT) and German Cancer Research Center (DKFZ), Heidelberg, Germany
⨯
Jan C. Brase,

Current address: Sividon Diagnostics GmbH, Köln, Germany.

Affiliation Unit Cancer Genome Research, Division of Molecular Genetics, National Center for Tumor Diseases (NCT) and German Cancer Research Center (DKFZ), Heidelberg, Germany
⨯
Stefan T. Börno,

Affiliations Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany, Department of Biology, Chemistry and Pharmacy, Free University Berlin, Berlin, Germany
⨯
Maria Fälth,

Affiliation Unit Cancer Genome Research, Division of Molecular Genetics, National Center for Tumor Diseases (NCT) and German Cancer Research Center (DKFZ), Heidelberg, Germany
⨯
Ruprecht Kuner,

Affiliation Unit Cancer Genome Research, Division of Molecular Genetics, National Center for Tumor Diseases (NCT) and German Cancer Research Center (DKFZ), Heidelberg, Germany
⨯
Hans Lehrach,

Affiliation Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany
⨯
Michal R. Schweiger,

Affiliation Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany
⨯
Holger Sültmann

Affiliation Unit Cancer Genome Research, Division of Molecular Genetics, National Center for Tumor Diseases (NCT) and German Cancer Research Center (DKFZ), Heidelberg, Germany
⨯

ERG Induces Epigenetic Activation of Tudor Domain-Containing Protein 1 (TDRD1) in ERG Rearrangement-Positive Prostate Cancer

Lukasz A. Kacprzyk,
Mark Laible,
Tatjana Andrasiuk,
Jan C. Brase,
Stefan T. Börno,
Maria Fälth,
Ruprecht Kuner,
Hans Lehrach,
Michal R. Schweiger,
Holger Sültmann

Published: March 29, 2013
https://doi.org/10.1371/journal.pone.0059976

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DNA methylation
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DNA transcription
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Small interfering RNA
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