A Hepatitis C Virus (HCV) Vaccine Comprising Envelope Glycoproteins gpE1/gpE2 Derived from a Single Isolate Elicits Broad Cross-Genotype Neutralizing Antibodies in Humans

• John Lok Man Law ,

  * E-mail: llaw@ualberta.ca (JLML); michael.houghton@ualberta.ca (MH)

  Affiliation Li Ka Shing Institute of Virology, Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Canada

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• Chao Chen,

  Affiliation Li Ka Shing Institute of Virology, Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Canada

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• Jason Wong,

  Affiliation Li Ka Shing Institute of Virology, Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Canada

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• Darren Hockman,

  Affiliation Li Ka Shing Institute of Virology, Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Canada

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• Deanna M. Santer,

  Affiliation Li Ka Shing Institute of Virology, Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Canada

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• Sharon E. Frey,

  Affiliation Department of Internal Medicine, Saint Louis University School of Medicine, Saint Louis, Missouri, United States of America

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• Robert B. Belshe,

  Affiliation Department of Internal Medicine, Saint Louis University School of Medicine, Saint Louis, Missouri, United States of America

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• Takaji Wakita,

  Affiliation Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan

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• Jens Bukh,

  Affiliation Copenhagen Hepatitis C Program, Department of Infectious Diseases and Clinical Research Centre, Copenhagen University Hospital, Hvidovre and Department of International Health, Immunology and Microbiology, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark

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• Christopher T. Jones,

  Affiliation Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, New York, United States of America

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• Charles M. Rice,

  Affiliation Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, New York, United States of America

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• Sergio Abrignani,

  Affiliation Istituto Nazionale Genetica Molecolare, Milan, Italy

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• D. Lorne Tyrrell,

  Affiliation Li Ka Shing Institute of Virology, Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Canada

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• Michael Houghton

  * E-mail: llaw@ualberta.ca (JLML); michael.houghton@ualberta.ca (MH)

  Affiliation Li Ka Shing Institute of Virology, Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Canada

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