Preferential Binding of Hot Spot Mutant p53 Proteins to Supercoiled DNA In Vitro and in Cells

Marie Brázdová; Lucie Navrátilová; Vlastimil Tichý; Kateřina Němcová; Matej Lexa; Roman Hrstka; Petr Pečinka; Matej Adámik; Borivoj Vojtesek; Emil Paleček; Wolfgang Deppert; Miroslav Fojta

doi:10.1371/journal.pone.0059567

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Open Access

Peer-reviewed

Research Article

Preferential Binding of Hot Spot Mutant p53 Proteins to Supercoiled DNA In Vitro and in Cells

Marie Brázdová ,

* E-mail: maruska@ibp.cz

Affiliation Department of Biophysical Chemistry and Molecular Oncology, Institute of Biophysics, Academy of Sciences of the Czech Republic, v.v.i., Brno, Czech Republic
⨯
Lucie Navrátilová,

Affiliation Department of Biophysical Chemistry and Molecular Oncology, Institute of Biophysics, Academy of Sciences of the Czech Republic, v.v.i., Brno, Czech Republic
⨯
Vlastimil Tichý,

Affiliation Department of Biophysical Chemistry and Molecular Oncology, Institute of Biophysics, Academy of Sciences of the Czech Republic, v.v.i., Brno, Czech Republic
⨯
Kateřina Němcová,

Affiliation Department of Biophysical Chemistry and Molecular Oncology, Institute of Biophysics, Academy of Sciences of the Czech Republic, v.v.i., Brno, Czech Republic
⨯
Matej Lexa,

Affiliation Faculty of Informatics, Masaryk University, Brno, Czech Republic
⨯
Roman Hrstka,

Affiliation Regional Center for Applied Molecular Oncology, Masaryk Memorial Cancer Institute, Brno, Czech Republic
⨯
Petr Pečinka,

Affiliations Department of Biophysical Chemistry and Molecular Oncology, Institute of Biophysics, Academy of Sciences of the Czech Republic, v.v.i., Brno, Czech Republic, Environmental Center, Faculty of Science, University of Ostrava, Ostrava, Czech Republic
⨯
Matej Adámik,

Affiliation Department of Biophysical Chemistry and Molecular Oncology, Institute of Biophysics, Academy of Sciences of the Czech Republic, v.v.i., Brno, Czech Republic
⨯
Borivoj Vojtesek,

Affiliation Regional Center for Applied Molecular Oncology, Masaryk Memorial Cancer Institute, Brno, Czech Republic
⨯
Emil Paleček,

Affiliation Department of Biophysical Chemistry and Molecular Oncology, Institute of Biophysics, Academy of Sciences of the Czech Republic, v.v.i., Brno, Czech Republic
⨯
Wolfgang Deppert,

Affiliation Department of Tumor Virology, Heinrich-Pette-Institute, Leibniz Institute for Experimental Virology, Hamburg, Germany
⨯
Miroslav Fojta

Affiliations Department of Biophysical Chemistry and Molecular Oncology, Institute of Biophysics, Academy of Sciences of the Czech Republic, v.v.i., Brno, Czech Republic, Central European Institute of Technology, Masaryk University, Brno, Czech Republic
⨯

Preferential Binding of Hot Spot Mutant p53 Proteins to Supercoiled DNA In Vitro and in Cells

Marie Brázdová,
Lucie Navrátilová,
Vlastimil Tichý,
Kateřina Němcová,
Matej Lexa,
Roman Hrstka,
Petr Pečinka,
Matej Adámik,
Borivoj Vojtesek,
Emil Paleček

Published: March 26, 2013
https://doi.org/10.1371/journal.pone.0059567

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