A Novel Splice-Site Mutation in Angiotensin I-Converting Enzyme (ACE) Gene, c.3691+1G>A (IVS25+1G>A), Causes a Dramatic Increase in Circulating ACE through Deletion of the Transmembrane Anchor

• Alexandre Persu ,

  * E-mail: alexandre.persu@uclouvain.be

  Affiliations Pole of Cardiovascular Research, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, Brussels, Belgium, Division of Cardiology, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium

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• Michel Lambert,

  Affiliation Division of Internal Medicine, Cliniques Universitaires Saint-Luc, Université catholique de Louvain, Brussels, Belgium

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• Jaap Deinum,

  Affiliation Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands

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• Marta Cossu,

  Affiliations Department of Rheumatology, Radboud University Medical Center, Nijmegen, The Netherlands, Department of Rheumatology, University Medical Center, Utrecht, The Netherlands

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• Nathalie de Visscher,

  Affiliation Division of Internal Medicine, Cliniques Universitaires Saint-Luc, Université catholique de Louvain, Brussels, Belgium

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• Leonid Irenge,

  Affiliation Center of Applied Molecular Technologies, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain, Brussels, Belgium

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• Jerôme Ambroise,

  Affiliation Center of Applied Molecular Technologies, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain, Brussels, Belgium

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• Jean-Marc Minon,

  Affiliation Department of Laboratory Medicine, Transfusion and Thrombosis-Haemostasis Unit, CHR de la Citadelle, Liège, Belgium

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• Andrew B. Nesterovitch,

  Affiliation Department of Dermatology, Rush University, Chicago, Illinois, United States of America

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• Alexander Churbanov,

  Affiliation Biology Department, New Mexico State University, Las Cruces, New Mexico, United States of America

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• Isolda A. Popova,

  Affiliation Institute for Chemistry of Life, Northwestern University, Evanston, Illinois, United States of America

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• Sergei M. Danilov,

  Affiliations Institute for Personalized Respiratory Medicine, University of Illinois at Chicago, Chicago, Illinois, United States of America, Department of Anesthesiology, University of Illinois at Chicago, Chicago, Illinois, United States of America

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• A. H. Jan Danser,

  Affiliation Division of Pharmacology and Vascular Medicine, Department of Internal Medicine, Erasmus University, Rotterdam, The Netherlands

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• Jean-Luc Gala

  Affiliation Center of Applied Molecular Technologies, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain, Brussels, Belgium

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