Pre-Diagnostic Leukocyte Genomic DNA Methylation and the Risk of Colorectal Cancer in Women

Hongmei Nan; Edward L. Giovannucci; Kana Wu; Jacob Selhub; Ligi Paul; Bernard Rosner; Charles S. Fuchs; Eunyoung Cho

doi:10.1371/journal.pone.0059455

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Open Access

Peer-reviewed

Research Article

Pre-Diagnostic Leukocyte Genomic DNA Methylation and the Risk of Colorectal Cancer in Women

Hongmei Nan,

Affiliations Division of Cancer Epidemiology, Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland, United States of America, Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
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Edward L. Giovannucci,

Affiliations Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America, Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, United States of America, Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America
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Kana Wu,

Affiliation Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, United States of America
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Jacob Selhub,

Affiliation Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts, United States of America
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Ligi Paul,

Affiliation Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts, United States of America
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Bernard Rosner,

Affiliations Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America, Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, United States of America
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Charles S. Fuchs,

Affiliations Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America, Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts, United States of America
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Eunyoung Cho

* E-mail: eunyoung.cho@channing.harvard.edu

Affiliation Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
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Pre-Diagnostic Leukocyte Genomic DNA Methylation and the Risk of Colorectal Cancer in Women

Hongmei Nan,
Edward L. Giovannucci,
Kana Wu,
Jacob Selhub,
Ligi Paul,
Bernard Rosner,
Charles S. Fuchs,
Eunyoung Cho

Published: April 1, 2013
https://doi.org/10.1371/journal.pone.0059455

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DNA methylation
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Colorectal cancer
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Cancer genomics
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Cancer risk factors
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White blood cells
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Methylation
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DNA metabolism
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Adenomas
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