Differential Pre-mRNA Splicing Regulates Nnat Isoforms in the Hypothalamus after Gastric Bypass Surgery in Mice

William R. Scott; Cigdem Gelegen; Keval Chandarana; Efthimia Karra; Ahmed Yousseif; Chloé Amouyal; Agharul I. Choudhury; Fabrizio Andreelli; Dominic J. Withers; Rachel L. Batterham

doi:10.1371/journal.pone.0059407

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Open Access

Peer-reviewed

Research Article

Differential Pre-mRNA Splicing Regulates Nnat Isoforms in the Hypothalamus after Gastric Bypass Surgery in Mice

William R. Scott,

Affiliation Centre for Obesity Research, Rayne Institute, Department of Medicine, University College London, London, United Kingdom
⨯
Cigdem Gelegen,

Affiliation Centre for Obesity Research, Rayne Institute, Department of Medicine, University College London, London, United Kingdom
⨯
Keval Chandarana,

Affiliation Centre for Obesity Research, Rayne Institute, Department of Medicine, University College London, London, United Kingdom
⨯
Efthimia Karra,

Affiliation Centre for Obesity Research, Rayne Institute, Department of Medicine, University College London, London, United Kingdom
⨯
Ahmed Yousseif,

Affiliation Centre for Obesity Research, Rayne Institute, Department of Medicine, University College London, London, United Kingdom
⨯
Chloé Amouyal,

Affiliation Pitié-Salpêtrière Hospital, Assistance Publique-Hôpitaux de Paris, Cardiometabolic Department, Pierre et Marie Curie University, Institut National de la Santé et de la Recherche Médicale, Paris, France
⨯
Agharul I. Choudhury,

Affiliation Metabolic Signalling Group, Medical Research Council Clinical Sciences Centre, Imperial College London, London, United Kingdom
⨯
Fabrizio Andreelli,

Affiliation Pitié-Salpêtrière Hospital, Assistance Publique-Hôpitaux de Paris, Cardiometabolic Department, Pierre et Marie Curie University, Institut National de la Santé et de la Recherche Médicale, Paris, France
⨯
Dominic J. Withers,

Affiliation Metabolic Signalling Group, Medical Research Council Clinical Sciences Centre, Imperial College London, London, United Kingdom
⨯
Rachel L. Batterham

* E-mail: r.batterham@ucl.ac.uk

Affiliation Centre for Obesity Research, Rayne Institute, Department of Medicine, University College London, London, United Kingdom
⨯

Differential Pre-mRNA Splicing Regulates Nnat Isoforms in the Hypothalamus after Gastric Bypass Surgery in Mice

William R. Scott,
Cigdem Gelegen,
Keval Chandarana,
Efthimia Karra,
Ahmed Yousseif,
Chloé Amouyal,
Agharul I. Choudhury,
Fabrizio Andreelli,
Dominic J. Withers,
Rachel L. Batterham

Published: March 20, 2013
https://doi.org/10.1371/journal.pone.0059407

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