Calpain and Reactive Oxygen Species Targets Bax for Mitochondrial Permeabilisation and Caspase Activation in Zerumbone Induced Apoptosis

Praveen K. Sobhan; Mahendra Seervi; Lokesh Deb; Saneesh Varghese; Anjana Soman; Jeena Joseph; Krupa Ann Mathew; Godi Raghu; George Thomas; Sreekumar E; Manjula S; Santosh Kumar T. R

doi:10.1371/journal.pone.0059350

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Open Access

Peer-reviewed

Research Article

Calpain and Reactive Oxygen Species Targets Bax for Mitochondrial Permeabilisation and Caspase Activation in Zerumbone Induced Apoptosis

Praveen K. Sobhan,

Affiliation Cancer Research Program, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, Kerala, India
⨯
Mahendra Seervi,

Affiliation Cancer Research Program, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, Kerala, India
⨯
Lokesh Deb,

Affiliation Institute of Bioresource and Sustainable Development, Imphal, Manipur, India
⨯
Saneesh Varghese,

Affiliation Cancer Research Program, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, Kerala, India
⨯
Anjana Soman,

Affiliation Cancer Research Program, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, Kerala, India
⨯
Jeena Joseph,

Affiliation Cancer Research Program, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, Kerala, India
⨯
Krupa Ann Mathew,

Affiliation Cancer Research Program, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, Kerala, India
⨯
Godi Raghu,

Affiliation Cancer Research Program, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, Kerala, India
⨯
George Thomas,

Affiliation Spice Genomics, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, Kerala, India
⨯
Sreekumar E,

Affiliation Viral Disease Biology Program, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, Kerala, India
⨯
Manjula S,

Affiliation Spice Genomics, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, Kerala, India
⨯
Santosh Kumar T. R

* E-mail: trsanthosh@rgcb.res.in

Affiliation Cancer Research Program, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, Kerala, India
⨯

Calpain and Reactive Oxygen Species Targets Bax for Mitochondrial Permeabilisation and Caspase Activation in Zerumbone Induced Apoptosis

Praveen K. Sobhan,
Mahendra Seervi,
Lokesh Deb,
Saneesh Varghese,
Anjana Soman,
Jeena Joseph,
Krupa Ann Mathew,
Godi Raghu,
George Thomas,
Sreekumar E

Published: April 9, 2013
https://doi.org/10.1371/journal.pone.0059350

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Apoptosis
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Mitochondria
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Cell death
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Fluorescence resonance energy transfer
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Cell staining
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Condensation
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Endoplasmic reticulum
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