The Ketamine Analogue Methoxetamine and 3- and 4-Methoxy Analogues of Phencyclidine Are High Affinity and Selective Ligands for the Glutamate NMDA Receptor

• Bryan L. Roth,

  Affiliation NIMH Psychoactive Drug Screening Program, Department of Pharmacology and Division of Chemical Biology and Medicinal Chemistry, University of North Carolina Chapel Hill Medical School, Chapel Hill, North Carolina, United States of America

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• Simon Gibbons,

  Affiliation Department of Pharmaceutical and Biological Chemistry, UCL School of Pharmacy, London, United Kingdom

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• Warunya Arunotayanun,

  Affiliation Department of Pharmaceutical and Biological Chemistry, UCL School of Pharmacy, London, United Kingdom

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• Xi-Ping Huang,

  Affiliation NIMH Psychoactive Drug Screening Program, Department of Pharmacology and Division of Chemical Biology and Medicinal Chemistry, University of North Carolina Chapel Hill Medical School, Chapel Hill, North Carolina, United States of America

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• Vincent Setola,

  Affiliation NIMH Psychoactive Drug Screening Program, Department of Pharmacology and Division of Chemical Biology and Medicinal Chemistry, University of North Carolina Chapel Hill Medical School, Chapel Hill, North Carolina, United States of America

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• Ric Treble,

  Affiliation LGC Forensics, London, United Kingdom

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• Les Iversen

  * E-mail: les.iversen@pharm.ox.ac.uk

  Affiliation Department of Pharmacology, University of Oxford, Oxford, United Kingdom

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