Cartilage–Specific Over-Expression of CCN Family Member 2/Connective Tissue Growth Factor (CCN2/CTGF) Stimulates Insulin-Like Growth Factor Expression and Bone Growth

Nao Tomita; Takako Hattori; Shinsuke Itoh; Eriko Aoyama; Mayumi Yao; Takashi Yamashiro; Masaharu Takigawa

doi:10.1371/journal.pone.0059226

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Peer-reviewed

Research Article

Cartilage–Specific Over-Expression of CCN Family Member 2/Connective Tissue Growth Factor (CCN2/CTGF) Stimulates Insulin-Like Growth Factor Expression and Bone Growth

Nao Tomita,

Affiliations Department of Biochemistry and Molecular Dentistry, Okayama University Dental School, Okayama, Japan, Department of Orthodontics, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University Dental School, Okayama, Japan
⨯
Takako Hattori ,

* E-mail: hattorit@md.okayama-u.ac.jp (TH); takigawa@md.okayama-u.ac.jp (MT)

Affiliation Department of Biochemistry and Molecular Dentistry, Okayama University Dental School, Okayama, Japan
⨯
Shinsuke Itoh,

Affiliations Department of Biochemistry and Molecular Dentistry, Okayama University Dental School, Okayama, Japan, Department of Orthodontics, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University Dental School, Okayama, Japan
⨯
Eriko Aoyama,

Affiliation Biodental Research Center, Okayama University Dental School, Okayama, Japan
⨯
Mayumi Yao,

Affiliation Department of Biochemistry and Molecular Dentistry, Okayama University Dental School, Okayama, Japan
⨯
Takashi Yamashiro,

Affiliation Department of Orthodontics, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University Dental School, Okayama, Japan
⨯
Masaharu Takigawa

* E-mail: hattorit@md.okayama-u.ac.jp (TH); takigawa@md.okayama-u.ac.jp (MT)

Affiliations Department of Biochemistry and Molecular Dentistry, Okayama University Dental School, Okayama, Japan, Biodental Research Center, Okayama University Dental School, Okayama, Japan
⨯

Cartilage–Specific Over-Expression of CCN Family Member 2/Connective Tissue Growth Factor (CCN2/CTGF) Stimulates Insulin-Like Growth Factor Expression and Bone Growth

Nao Tomita,
Takako Hattori,
Shinsuke Itoh,
Eriko Aoyama,
Mayumi Yao,
Takashi Yamashiro,
Masaharu Takigawa

Published: March 28, 2013
https://doi.org/10.1371/journal.pone.0059226

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