Interleukin-27 Is a Potent Inhibitor of cis HIV-1 Replication in Monocyte-Derived Dendritic Cells via a Type I Interferon-Independent Pathway

Qian Chen; Sanjay Swaminathan; De Yang; Lue Dai; Hongyan Sui; Jun Yang; Ronald L. Hornung; Yanmei Wang; Da Wei Huang; Xiaojun Hu; Richard A. Lempicki; Tomozumi Imamichi

doi:10.1371/journal.pone.0059194

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Open Access

Peer-reviewed

Research Article

Interleukin-27 Is a Potent Inhibitor of cis HIV-1 Replication in Monocyte-Derived Dendritic Cells via a Type I Interferon-Independent Pathway

Qian Chen ,

Contributed equally to this work with: Qian Chen, Sanjay Swaminathan

Affiliation Laboratory of Human Retrovirology, Applied and Developmental Research Directorate (ADD), Science Application International Corporation (SAIC)-Frederick, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America
⨯
Sanjay Swaminathan ,

Contributed equally to this work with: Qian Chen, Sanjay Swaminathan

Affiliation Laboratory of Human Retrovirology, Applied and Developmental Research Directorate (ADD), Science Application International Corporation (SAIC)-Frederick, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America
⨯
De Yang,

Affiliation Laboratory of Molecular Immunoregulation, Basic Research Program Directorate, SAIC-Frederick, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America
⨯
Lue Dai,

Affiliation Laboratory of Human Retrovirology, Applied and Developmental Research Directorate (ADD), Science Application International Corporation (SAIC)-Frederick, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America
⨯
Hongyan Sui,

Affiliation Laboratory of Human Retrovirology, Applied and Developmental Research Directorate (ADD), Science Application International Corporation (SAIC)-Frederick, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America
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Jun Yang,

Affiliation Laboratory of Immunopathogenesis and Bioinformatics, ADD, SAIC-Frederick, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America
⨯
Ronald L. Hornung,

Affiliation Immunological Monitoring Laboratory, ADD, SAIC-Frederick, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America
⨯
Yanmei Wang,

Affiliation Immunological Monitoring Laboratory, ADD, SAIC-Frederick, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America
⨯
Da Wei Huang,

Affiliation Laboratory of Immunopathogenesis and Bioinformatics, ADD, SAIC-Frederick, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America
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Xiaojun Hu,

Affiliation Laboratory of Immunopathogenesis and Bioinformatics, ADD, SAIC-Frederick, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America
⨯
Richard A. Lempicki,

Affiliation Laboratory of Immunopathogenesis and Bioinformatics, ADD, SAIC-Frederick, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America
⨯
Tomozumi Imamichi

* E-mail: timamichi@mail.nih.gov

Affiliation Laboratory of Human Retrovirology, Applied and Developmental Research Directorate (ADD), Science Application International Corporation (SAIC)-Frederick, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America
⨯

Interleukin-27 Is a Potent Inhibitor of cis HIV-1 Replication in Monocyte-Derived Dendritic Cells via a Type I Interferon-Independent Pathway

Qian Chen,
Sanjay Swaminathan,
De Yang,
Lue Dai,
Hongyan Sui,
Jun Yang,
Ronald L. Hornung,
Yanmei Wang,
Da Wei Huang,
Xiaojun Hu

Published: March 20, 2013
https://doi.org/10.1371/journal.pone.0059194

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