A Large Scale Gene-Centric Association Study of Lung Function in Newly-Hired Female Cotton Textile Workers with Endotoxin Exposure

Ruyang Zhang; Yang Zhao; Minjie Chu; Amar Mehta; Yongyue Wei; Yao Liu; Pengcheng Xun; Jianling Bai; Hao Yu; Li Su; Hongxi Zhang; Zhibin Hu; Hongbing Shen; Feng Chen; David C. Christiani

doi:10.1371/journal.pone.0059035

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Peer-reviewed

Research Article

A Large Scale Gene-Centric Association Study of Lung Function in Newly-Hired Female Cotton Textile Workers with Endotoxin Exposure

Ruyang Zhang ,

Contributed equally to this work with: Ruyang Zhang, Yang Zhao

Affiliations Department of Epidemiology and Biostatistics and Ministry of Education (MOE) Key Lab for Modern Toxicology, School of Public Health, Nanjing Medical University, Nanjing, China, Section of Clinical Epidemiology, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Cancer Center, Nanjing Medical University, Nanjing, China
⨯
Yang Zhao ,

Contributed equally to this work with: Ruyang Zhang, Yang Zhao

Affiliations Department of Epidemiology and Biostatistics and Ministry of Education (MOE) Key Lab for Modern Toxicology, School of Public Health, Nanjing Medical University, Nanjing, China, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, United States of America
⨯
Minjie Chu,

Affiliations Department of Epidemiology and Biostatistics and Ministry of Education (MOE) Key Lab for Modern Toxicology, School of Public Health, Nanjing Medical University, Nanjing, China, Section of Clinical Epidemiology, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Cancer Center, Nanjing Medical University, Nanjing, China
⨯
Amar Mehta,

Affiliations Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, United States of America, Swiss Tropical and Public Health Institute, Basel, Switzerland, University of Basel, Basel, Switzerland
⨯
Yongyue Wei,

Affiliations Department of Epidemiology and Biostatistics and Ministry of Education (MOE) Key Lab for Modern Toxicology, School of Public Health, Nanjing Medical University, Nanjing, China, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, United States of America
⨯
Yao Liu,

Affiliations Department of Epidemiology and Biostatistics and Ministry of Education (MOE) Key Lab for Modern Toxicology, School of Public Health, Nanjing Medical University, Nanjing, China, Section of Clinical Epidemiology, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Cancer Center, Nanjing Medical University, Nanjing, China
⨯
Pengcheng Xun,

Affiliation Department of Epidemiology and Biostatistics, School of Public Health, Indiana University Bloomington, Bloomington, Indiana, United States of America
⨯
Jianling Bai,

Affiliation Department of Epidemiology and Biostatistics and Ministry of Education (MOE) Key Lab for Modern Toxicology, School of Public Health, Nanjing Medical University, Nanjing, China
⨯
Hao Yu,

Affiliation Department of Epidemiology and Biostatistics and Ministry of Education (MOE) Key Lab for Modern Toxicology, School of Public Health, Nanjing Medical University, Nanjing, China
⨯
Li Su,

Affiliation Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, United States of America
⨯
Hongxi Zhang,

Affiliation Putuo District Peoples Hospital, Shanghai Second Medical University, Shanghai, China
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Zhibin Hu,

Affiliations Department of Epidemiology and Biostatistics and Ministry of Education (MOE) Key Lab for Modern Toxicology, School of Public Health, Nanjing Medical University, Nanjing, China, Section of Clinical Epidemiology, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Cancer Center, Nanjing Medical University, Nanjing, China
⨯
Hongbing Shen,

Affiliations Department of Epidemiology and Biostatistics and Ministry of Education (MOE) Key Lab for Modern Toxicology, School of Public Health, Nanjing Medical University, Nanjing, China, Section of Clinical Epidemiology, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Cancer Center, Nanjing Medical University, Nanjing, China
⨯
Feng Chen ,

* E-mail: fengchen@njmu.edu.cn (FC); dchris@hsph.harvard.edu (DCC)

Affiliation Department of Epidemiology and Biostatistics and Ministry of Education (MOE) Key Lab for Modern Toxicology, School of Public Health, Nanjing Medical University, Nanjing, China
⨯
David C. Christiani

* E-mail: fengchen@njmu.edu.cn (FC); dchris@hsph.harvard.edu (DCC)

Affiliations Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, United States of America, Pulmonary and Critical Care Unit, Department of Medicine, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts, United States of America
⨯

A Large Scale Gene-Centric Association Study of Lung Function in Newly-Hired Female Cotton Textile Workers with Endotoxin Exposure

Ruyang Zhang,
Yang Zhao,
Minjie Chu,
Amar Mehta,
Yongyue Wei,
Yao Liu,
Pengcheng Xun,
Jianling Bai,
Hao Yu,
Li Su

Published: March 19, 2013
https://doi.org/10.1371/journal.pone.0059035

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