Mitochondrial Biogenesis Drives a Vicious Cycle of Metabolic Insufficiency and Mitochondrial DNA Deletion Mutation Accumulation in Aged Rat Skeletal Muscle Fibers

Open Access

Peer-reviewed

Research Article

Allen Herbst,

Affiliation Centre for Prions and Protein Folding Diseases, Agriculture Food and Nutritional Sciences, University of Alberta, Edmonton, Canada
⨯
Chad J. Johnson,

Affiliation Department of Soil Sciences, University of Wisconsin-Madison, Madison, Wisconsin, United States of America
⨯
Kayla Hynes,

Affiliation Centre for Prions and Protein Folding Diseases, Department of Biological Sciences, University of Alberta, Edmonton, Alberta, Canada
⨯
Debbie McKenzie,

Affiliation Centre for Prions and Protein Folding Diseases, Department of Biological Sciences, University of Alberta, Edmonton, Alberta, Canada
⨯
Judd M. Aiken

* E-mail: Judd.Aiken@ualberta.ca

Affiliation Centre for Prions and Protein Folding Diseases, Agriculture Food and Nutritional Sciences, University of Alberta, Edmonton, Canada
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Mitochondria
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Deletion mutation
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Mitochondrial DNA
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Muscle fibers
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Skeletal muscle fibers
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Biosynthesis
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Genomics
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Electron transport chain
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