Functional Characterisation of Three O-methyltransferases Involved in the Biosynthesis of Phenolglycolipids in Mycobacterium tuberculosis

Roxane Simeone; Gaëlle Huet; Patricia Constant; Wladimir Malaga; Anne Lemassu; Françoise Laval; Mamadou Daffé; Christophe Guilhot; Christian Chalut

doi:10.1371/journal.pone.0058954

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Peer-reviewed

Research Article

Functional Characterisation of Three O-methyltransferases Involved in the Biosynthesis of Phenolglycolipids in Mycobacterium tuberculosis

Roxane Simeone,

Current address: Present address: Unité de Pathogénomique Mycobactérienne Intégrée, Institut Pasteur, Paris, France

Affiliations Centre national de la recherche scientifique, Institut de Pharmacologie et de Biologie Structurale, Toulouse, France, Université de Toulouse, Université Paul Sabatier, Institut de Pharmacologie et de Biologie Structurale, Toulouse, France
⨯
Gaëlle Huet,

Current address: Present address: Laboratoire des Interactions Plantes-Microorganismes (LIPM), Castanet-Tolosan, France

Affiliations Centre national de la recherche scientifique, Institut de Pharmacologie et de Biologie Structurale, Toulouse, France, Université de Toulouse, Université Paul Sabatier, Institut de Pharmacologie et de Biologie Structurale, Toulouse, France
⨯
Patricia Constant,

Affiliations Centre national de la recherche scientifique, Institut de Pharmacologie et de Biologie Structurale, Toulouse, France, Université de Toulouse, Université Paul Sabatier, Institut de Pharmacologie et de Biologie Structurale, Toulouse, France
⨯
Wladimir Malaga,

Affiliations Centre national de la recherche scientifique, Institut de Pharmacologie et de Biologie Structurale, Toulouse, France, Université de Toulouse, Université Paul Sabatier, Institut de Pharmacologie et de Biologie Structurale, Toulouse, France
⨯
Anne Lemassu,

Affiliations Centre national de la recherche scientifique, Institut de Pharmacologie et de Biologie Structurale, Toulouse, France, Université de Toulouse, Université Paul Sabatier, Institut de Pharmacologie et de Biologie Structurale, Toulouse, France
⨯
Françoise Laval,

Affiliations Centre national de la recherche scientifique, Institut de Pharmacologie et de Biologie Structurale, Toulouse, France, Université de Toulouse, Université Paul Sabatier, Institut de Pharmacologie et de Biologie Structurale, Toulouse, France
⨯
Mamadou Daffé,

Affiliations Centre national de la recherche scientifique, Institut de Pharmacologie et de Biologie Structurale, Toulouse, France, Université de Toulouse, Université Paul Sabatier, Institut de Pharmacologie et de Biologie Structurale, Toulouse, France
⨯
Christophe Guilhot,

Affiliations Centre national de la recherche scientifique, Institut de Pharmacologie et de Biologie Structurale, Toulouse, France, Université de Toulouse, Université Paul Sabatier, Institut de Pharmacologie et de Biologie Structurale, Toulouse, France
⨯
Christian Chalut

* E-mail: christian.chalut@ipbs.fr

Affiliations Centre national de la recherche scientifique, Institut de Pharmacologie et de Biologie Structurale, Toulouse, France, Université de Toulouse, Université Paul Sabatier, Institut de Pharmacologie et de Biologie Structurale, Toulouse, France
⨯

Functional Characterisation of Three O-methyltransferases Involved in the Biosynthesis of Phenolglycolipids in Mycobacterium tuberculosis

Roxane Simeone,
Gaëlle Huet,
Patricia Constant,
Wladimir Malaga,
Anne Lemassu,
Françoise Laval,
Mamadou Daffé,
Christophe Guilhot,
Christian Chalut

Published: March 11, 2013
https://doi.org/10.1371/journal.pone.0058954

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Mycobacterium tuberculosis
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Matrix-assisted laser desorption ionization time-of-flight mass spectrometry
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Glycolipids
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Mutant strains
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Genetic loci
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Protons
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Methyltransferases
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Genomics
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