A Novel Synthetic Microtubule Inhibitor, MPT0B214 Exhibits Antitumor Activity in Human Tumor Cells through Mitochondria-Dependent Intrinsic Pathway

Nai-Jung Chiang; Ching-I Lin; Jing-Ping Liou; Ching-Chuan Kuo; Chi-Yen Chang; Li-Tzong Chen; Jang-Yang Chang

doi:10.1371/journal.pone.0058953

Loading metrics

Open Access

Peer-reviewed

Research Article

A Novel Synthetic Microtubule Inhibitor, MPT0B214 Exhibits Antitumor Activity in Human Tumor Cells through Mitochondria-Dependent Intrinsic Pathway

Nai-Jung Chiang ,

Contributed equally to this work with: Nai-Jung Chiang, Ching-I Lin

Affiliations National Institute of Cancer Research, National Health Research Institutes, Tainan, Taiwan, ROC, Division of Hematology/Oncology, Department of Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan, ROC
⨯
Ching-I Lin ,

Contributed equally to this work with: Nai-Jung Chiang, Ching-I Lin

Affiliations National Institute of Cancer Research, National Health Research Institutes, Tainan, Taiwan, ROC, Division of Hematology/Oncology, Department of Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan, ROC, Division of Hematology/Oncology, Department of Internal Medicine, St. Martin De Porres Hospital, Chiayi, Taiwan, ROC
⨯
Jing-Ping Liou,

Affiliation School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei, Taiwan, ROC
⨯
Ching-Chuan Kuo,

Affiliation National Institute of Cancer Research, National Health Research Institutes, Tainan, Taiwan, ROC
⨯
Chi-Yen Chang,

Affiliation National Institute of Cancer Research, National Health Research Institutes, Tainan, Taiwan, ROC
⨯
Li-Tzong Chen,

Affiliations National Institute of Cancer Research, National Health Research Institutes, Tainan, Taiwan, ROC, Division of Hematology/Oncology, Department of Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan, ROC
⨯
Jang-Yang Chang

* E-mail: jychang@nhri.org.tw

Affiliations National Institute of Cancer Research, National Health Research Institutes, Tainan, Taiwan, ROC, Division of Hematology/Oncology, Department of Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan, ROC
⨯

A Novel Synthetic Microtubule Inhibitor, MPT0B214 Exhibits Antitumor Activity in Human Tumor Cells through Mitochondria-Dependent Intrinsic Pathway

Nai-Jung Chiang,
Ching-I Lin,
Jing-Ping Liou,
Ching-Chuan Kuo,
Chi-Yen Chang,
Li-Tzong Chen,
Jang-Yang Chang

Published: March 12, 2013
https://doi.org/10.1371/journal.pone.0058953

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Microtubules
Is the Subject Area "Microtubules" applicable to this article?

Thanks for your feedback.
Apoptosis
Is the Subject Area "Apoptosis" applicable to this article?

Thanks for your feedback.
Tubulins
Is the Subject Area "Tubulins" applicable to this article?

Thanks for your feedback.
Nasopharyngeal carcinoma
Is the Subject Area "Nasopharyngeal carcinoma" applicable to this article?

Thanks for your feedback.
Colchicine
Is the Subject Area "Colchicine" applicable to this article?

Thanks for your feedback.
Mitochondria
Is the Subject Area "Mitochondria" applicable to this article?

Thanks for your feedback.
HT29 cells
Is the Subject Area "HT29 cells" applicable to this article?

Thanks for your feedback.
Phosphorylation
Is the Subject Area "Phosphorylation" applicable to this article?

Thanks for your feedback.