Insulin-Receptor Substrate-2 (IRS-2) Is Required for Maintaining Glucokinase and Glucokinase Regulatory Protein Expression in Mouse Liver

Isabel Roncero; Elvira Alvarez; Carlos Acosta; Carmen Sanz; Pedro Barrio; Veronica Hurtado-Carneiro; Deborah Burks; Enrique Blázquez

doi:10.1371/journal.pone.0058797

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Peer-reviewed

Research Article

Insulin-Receptor Substrate-2 (IRS-2) Is Required for Maintaining Glucokinase and Glucokinase Regulatory Protein Expression in Mouse Liver

Isabel Roncero,

Affiliations The Center for Biomedical Research in Diabetes and Associated Metabolic Disorders (CIBERDEM), Madrid, Spain, Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Universidad Complutense de Madrid-Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain
⨯
Elvira Alvarez,

Affiliations The Center for Biomedical Research in Diabetes and Associated Metabolic Disorders (CIBERDEM), Madrid, Spain, Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Universidad Complutense de Madrid-Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain
⨯
Carlos Acosta,

Affiliations The Center for Biomedical Research in Diabetes and Associated Metabolic Disorders (CIBERDEM), Madrid, Spain, Centro de Investigación Príncipe Felipe, Valencia, Spain
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Carmen Sanz,

Affiliations The Center for Biomedical Research in Diabetes and Associated Metabolic Disorders (CIBERDEM), Madrid, Spain, Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Universidad Complutense de Madrid-Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain, Departamento de Biología Celular, Facultad de Medicina, Universidad Complutense de Madrid, Madrid, Spain
⨯
Pedro Barrio,

Affiliations The Center for Biomedical Research in Diabetes and Associated Metabolic Disorders (CIBERDEM), Madrid, Spain, Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Universidad Complutense de Madrid-Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain
⨯
Veronica Hurtado-Carneiro,

Affiliations The Center for Biomedical Research in Diabetes and Associated Metabolic Disorders (CIBERDEM), Madrid, Spain, Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Universidad Complutense de Madrid-Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain
⨯
Deborah Burks,

Affiliations The Center for Biomedical Research in Diabetes and Associated Metabolic Disorders (CIBERDEM), Madrid, Spain, Centro de Investigación Príncipe Felipe, Valencia, Spain
⨯
Enrique Blázquez

* E-mail: eblazquez@med.ucm.es

Affiliations The Center for Biomedical Research in Diabetes and Associated Metabolic Disorders (CIBERDEM), Madrid, Spain, Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Universidad Complutense de Madrid-Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain
⨯

Insulin-Receptor Substrate-2 (IRS-2) Is Required for Maintaining Glucokinase and Glucokinase Regulatory Protein Expression in Mouse Liver

Isabel Roncero,
Elvira Alvarez,
Carlos Acosta,
Carmen Sanz,
Pedro Barrio,
Veronica Hurtado-Carneiro,
Deborah Burks,
Enrique Blázquez

Published: April 1, 2013
https://doi.org/10.1371/journal.pone.0058797

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Glucose
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Insulin
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Glucose metabolism
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Gene expression
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Hypothalamus
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Protein expression
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Insulin resistance
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Insulin signaling
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