Kinetic and Structural Evidences on Human Prolidase Pathological Mutants Suggest Strategies for Enzyme Functional Rescue

• Roberta Besio,

  Affiliation Department of Molecular Medicine, Biochemistry Unit, University of Pavia, Pavia, Italy

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• Roberta Gioia,

  Affiliation Department of Molecular Medicine, Biochemistry Unit, University of Pavia, Pavia, Italy

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• Federica Cossu,

  Affiliation Department of BioSciences, CNR-IBF and CIMAINA, University of Milano, Milano, Italy

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• Enrico Monzani,

  Affiliation Department of Chemistry, University of Pavia, Pavia, Italy

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• Stefania Nicolis,

  Affiliation Department of Chemistry, University of Pavia, Pavia, Italy

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• Lucia Cucca,

  Affiliation Department of Chemistry, University of Pavia, Pavia, Italy

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• Antonella Profumo,

  Affiliation Department of Chemistry, University of Pavia, Pavia, Italy

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• Luigi Casella,

  Affiliation Department of Chemistry, University of Pavia, Pavia, Italy

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• Ruggero Tenni,

  Affiliation Department of Molecular Medicine, Biochemistry Unit, University of Pavia, Pavia, Italy

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• Martino Bolognesi,

  Affiliation Department of BioSciences, CNR-IBF and CIMAINA, University of Milano, Milano, Italy

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• Antonio Rossi,

  Affiliation Department of Molecular Medicine, Biochemistry Unit, University of Pavia, Pavia, Italy

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• Antonella Forlino

  * E-mail: aforlino@unipv.it

  Affiliation Department of Molecular Medicine, Biochemistry Unit, University of Pavia, Pavia, Italy

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