Monocyte Chemoattractant Protein-1/CCL2 Produced by Stromal Cells Promotes Lung Metastasis of 4T1 Murine Breast Cancer Cells

Teizo Yoshimura; O. M. Zack Howard; Toshihiro Ito; Masaki Kuwabara; Akihiro Matsukawa; Keqiang Chen; Ying Liu; Mingyong Liu; Joost J. Oppenheim; Ji Ming Wang

doi:10.1371/journal.pone.0058791

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Open Access

Peer-reviewed

Research Article

Monocyte Chemoattractant Protein-1/CCL2 Produced by Stromal Cells Promotes Lung Metastasis of 4T1 Murine Breast Cancer Cells

Teizo Yoshimura ,

* E-mail: yoshimut@mail.nih.gov

Affiliation Laboratory of Molecular Immunoregulation, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, United States of America
⨯
O. M. Zack Howard,

Affiliation Laboratory of Molecular Immunoregulation, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, United States of America
⨯
Toshihiro Ito,

Affiliation Department of Pathology and Experimental Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan
⨯
Masaki Kuwabara,

Affiliation Department of Pathology and Experimental Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan
⨯
Akihiro Matsukawa,

Affiliation Department of Pathology and Experimental Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan
⨯
Keqiang Chen,

Affiliation Laboratory of Molecular Immunoregulation, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, United States of America
⨯
Ying Liu,

Affiliation Laboratory of Molecular Immunoregulation, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, United States of America
⨯
Mingyong Liu,

Affiliation Laboratory of Molecular Immunoregulation, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, United States of America
⨯
Joost J. Oppenheim,

Affiliation Laboratory of Molecular Immunoregulation, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, United States of America
⨯
Ji Ming Wang

Affiliation Laboratory of Molecular Immunoregulation, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, United States of America
⨯

Monocyte Chemoattractant Protein-1/CCL2 Produced by Stromal Cells Promotes Lung Metastasis of 4T1 Murine Breast Cancer Cells

Teizo Yoshimura,
O. M. Zack Howard,
Toshihiro Ito,
Masaki Kuwabara,
Akihiro Matsukawa,
Keqiang Chen,
Ying Liu,
Mingyong Liu,
Joost J. Oppenheim,
Ji Ming Wang

Published: March 18, 2013
https://doi.org/10.1371/journal.pone.0058791

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Lung and intrathoracic tumors
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Secondary lung tumors
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Breast cancer
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Metastasis
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Metastatic tumors
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Macrophages
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Cancers and neoplasms
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