N-Substituted Benzyl Matrinic Acid Derivatives Inhibit Hepatitis C Virus (HCV) Replication through Down-Regulating Host Heat-Stress Cognate 70 (Hsc70) Expression

Na-Na Du; Zong-Gen Peng; Chong-Wen Bi; Sheng Tang; Ying-Hong Li; Jian-Rui Li; Yan-Ping Zhu; Jing-Pu Zhang; Yan-Xiang Wang; Jian-Dong Jiang; Dan-Qing Song

doi:10.1371/journal.pone.0058675

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Peer-reviewed

Research Article

N-Substituted Benzyl Matrinic Acid Derivatives Inhibit Hepatitis C Virus (HCV) Replication through Down-Regulating Host Heat-Stress Cognate 70 (Hsc70) Expression

Na-Na Du ,

Contributed equally to this work with: Na-Na Du, Zong-Gen Peng

Affiliation Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China
⨯
Zong-Gen Peng ,

Contributed equally to this work with: Na-Na Du, Zong-Gen Peng

Affiliation Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China
⨯
Chong-Wen Bi,

Affiliation Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China
⨯
Sheng Tang,

Affiliation Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China
⨯
Ying-Hong Li,

Affiliation Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China
⨯
Jian-Rui Li,

Affiliation Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China
⨯
Yan-Ping Zhu,

Affiliation Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China
⨯
Jing-Pu Zhang,

Affiliation Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China
⨯
Yan-Xiang Wang,

Affiliation Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China
⨯
Jian-Dong Jiang ,

* E-mail: jiang.jdong@163.com (J-DJ); songdanqingsdq@hotmail.com (D-QS)

Affiliations Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China, State Key Laboratory of Bioactive Substance and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
⨯
Dan-Qing Song

* E-mail: jiang.jdong@163.com (J-DJ); songdanqingsdq@hotmail.com (D-QS)

Affiliation Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China
⨯

N-Substituted Benzyl Matrinic Acid Derivatives Inhibit Hepatitis C Virus (HCV) Replication through Down-Regulating Host Heat-Stress Cognate 70 (Hsc70) Expression

Na-Na Du,
Zong-Gen Peng,
Chong-Wen Bi,
Sheng Tang,
Ying-Hong Li,
Jian-Rui Li,
Yan-Ping Zhu,
Jing-Pu Zhang,
Yan-Xiang Wang,
Jian-Dong Jiang

Published: March 14, 2013
https://doi.org/10.1371/journal.pone.0058675

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