Fatty Acid Ethyl Esters Induce Intestinal Epithelial Barrier Dysfunction via a Reactive Oxygen Species-Dependent Mechanism in a Three-Dimensional Cell Culture Model

Elhaseen Elamin; Ad Masclee; Kati Juuti-Uusitalo; Sven van IJzendoorn; Freddy Troost; Harm-Jan Pieters; Jan Dekker; Daisy Jonkers

doi:10.1371/journal.pone.0058561

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Peer-reviewed

Research Article

Fatty Acid Ethyl Esters Induce Intestinal Epithelial Barrier Dysfunction via a Reactive Oxygen Species-Dependent Mechanism in a Three-Dimensional Cell Culture Model

Elhaseen Elamin,

Affiliations Top Institute Food and Nutrition (TIFN), Wageningen, The Netherlands, Department of Internal Medicine, Maastricht University Medical Center, Maastricht, The Netherlands
⨯
Ad Masclee,

Affiliations Top Institute Food and Nutrition (TIFN), Wageningen, The Netherlands, Department of Internal Medicine, Maastricht University Medical Center, Maastricht, The Netherlands
⨯
Kati Juuti-Uusitalo,

Affiliations Top Institute Food and Nutrition (TIFN), Wageningen, The Netherlands, Institute of Biomedical Technology, University of Tampere, Tampere, Finland
⨯
Sven van IJzendoorn,

Affiliations Top Institute Food and Nutrition (TIFN), Wageningen, The Netherlands, Department of Cell Biology, University Medical Center Groningen, Groningen, The Netherlands
⨯
Freddy Troost,

Affiliations Top Institute Food and Nutrition (TIFN), Wageningen, The Netherlands, Department of Internal Medicine, Maastricht University Medical Center, Maastricht, The Netherlands
⨯
Harm-Jan Pieters,

Affiliation Department of Internal Medicine, Maastricht University Medical Center, Maastricht, The Netherlands
⨯
Jan Dekker,

Affiliations Top Institute Food and Nutrition (TIFN), Wageningen, The Netherlands, Department of Animal Sciences, Wageningen University, Wageningen, The Netherlands
⨯
Daisy Jonkers

* E-mail: d.jonkers@maastrichtuniversity.nl

Affiliations Top Institute Food and Nutrition (TIFN), Wageningen, The Netherlands, Department of Internal Medicine, Maastricht University Medical Center, Maastricht, The Netherlands
⨯

Fatty Acid Ethyl Esters Induce Intestinal Epithelial Barrier Dysfunction via a Reactive Oxygen Species-Dependent Mechanism in a Three-Dimensional Cell Culture Model

Elhaseen Elamin,
Ad Masclee,
Kati Juuti-Uusitalo,
Sven van IJzendoorn,
Freddy Troost,
Harm-Jan Pieters,
Jan Dekker,
Daisy Jonkers

Published: March 19, 2013
https://doi.org/10.1371/journal.pone.0058561

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Gastrointestinal tract
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Ethanol
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Permeability
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Caco-2 cells
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Oxidative stress
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Oleates
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Epithelial cells
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Antioxidants
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