Circulating Tumor Cells: Application as a Biomarker for Molecular Characterization and Predictor of Survival in an All-Comer Solid Tumor Phase I Clinical Study

Haifeng Bao; Patricia A. Burke; Jiaqi Huang; Xiaoru Chen; Philip Z. Brohawn; Yihong Yao; Robert J. Lechleider; Robert S. Sikorski; Manuela Buzoianu; Jianliang Zhang; Xiaoqing Shi; Laura K. Richman; Theresa M. LaVallee

doi:10.1371/journal.pone.0058557

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Open Access

Peer-reviewed

Research Article

Circulating Tumor Cells: Application as a Biomarker for Molecular Characterization and Predictor of Survival in an All-Comer Solid Tumor Phase I Clinical Study

Haifeng Bao,

Affiliation Department of Translational Sciences, MedImmune LLC, Gaithersburg, Maryland, United States of America
⨯
Patricia A. Burke,

Affiliation Department of Translational Sciences, MedImmune LLC, Gaithersburg, Maryland, United States of America
⨯
Jiaqi Huang,

Affiliation Department of Translational Sciences, MedImmune LLC, Gaithersburg, Maryland, United States of America
⨯
Xiaoru Chen,

Affiliation Department of Translational Sciences, MedImmune LLC, Gaithersburg, Maryland, United States of America
⨯
Philip Z. Brohawn,

Affiliation Department of Translational Sciences, MedImmune LLC, Gaithersburg, Maryland, United States of America
⨯
Yihong Yao,

Affiliation Department of Translational Sciences, MedImmune LLC, Gaithersburg, Maryland, United States of America
⨯
Robert J. Lechleider,

Affiliation Formerly at Clinical Development, MedImmune LLC, Gaithersburg, Maryland, United States of America
⨯
Robert S. Sikorski,

Affiliation Clinical Development, MedImmune LLC, Gaithersburg, Maryland, United States of America
⨯
Manuela Buzoianu,

Affiliation Formerly at Clinical Development, MedImmune LLC, Gaithersburg, Maryland, United States of America
⨯
Jianliang Zhang,

Affiliation Clinical Development, MedImmune LLC, Gaithersburg, Maryland, United States of America
⨯
Xiaoqing Shi,

Affiliation Department of Translational Sciences, MedImmune LLC, Gaithersburg, Maryland, United States of America
⨯
Laura K. Richman,

Affiliation Department of Translational Sciences, MedImmune LLC, Gaithersburg, Maryland, United States of America
⨯
Theresa M. LaVallee

* E-mail: LaValleeT@medimmune.com

Affiliation Department of Translational Sciences, MedImmune LLC, Gaithersburg, Maryland, United States of America
⨯

Circulating Tumor Cells: Application as a Biomarker for Molecular Characterization and Predictor of Survival in an All-Comer Solid Tumor Phase I Clinical Study

Haifeng Bao,
Patricia A. Burke,
Jiaqi Huang,
Xiaoru Chen,
Philip Z. Brohawn,
Yihong Yao,
Robert J. Lechleider,
Robert S. Sikorski,
Manuela Buzoianu,
Jianliang Zhang

Published: August 21, 2013
https://doi.org/10.1371/journal.pone.0058557

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